Matches in SemOpenAlex for { <https://semopenalex.org/work/W4243147628> ?p ?o ?g. }
Showing items 1 to 54 of
54
with 100 items per page.
- W4243147628 endingPage "67" @default.
- W4243147628 startingPage "67" @default.
- W4243147628 abstract "Three competing mathematical fitting models (a point‐by‐point estimation method, a linear fit method, and an isoconversion method) of chemical stability (related substance growth) when using high temperature data to predict room temperature shelf‐life were employed in a detailed comparison. In each case, complex degradant formation behavior was analyzed by both exponential and linear forms of the Arrhenius equation. A hypothetical reaction was used where a drug (A) degrades to a primary degradant (B), which in turn degrades to a secondary degradation product (C). Calculated data with the fitting models were compared with the projected room‐temperature shelf‐lives of B and C, using one to four time points (in addition to the origin) for each of three accelerated temperatures. Isoconversion methods were found to provide more accurate estimates of shelf‐life at ambient conditions. Of the methods for estimating isoconversion, bracketing the specification limit at each condition produced the best estimates and was considerably more accurate than when extrapolation was required. Good estimates of isoconversion produced similar shelf‐life estimates fitting either linear or nonlinear forms of the Arrhenius equation, whereas poor isoconversion estimates favored one method or the other depending on which condition was most in error. © 2014 Wiley Periodicals, Inc. and the American Pharmacists Association J Pharm Sci 103:3000–3006, 2014" @default.
- W4243147628 created "2022-05-12" @default.
- W4243147628 date "2000-12-07" @default.
- W4243147628 modified "2023-09-26" @default.
- W4243147628 title "The 5 Minute Toxicology Consult Edited by R.C. Dart, Lippincott Williams and Wilkins, Philadelphia, 2000, 738 pp. ISBN 0-683-30202-7; US$69.95" @default.
- W4243147628 doi "https://doi.org/10.1016/s0300-483x(00)00395-4" @default.
- W4243147628 hasPublicationYear "2000" @default.
- W4243147628 type Work @default.
- W4243147628 citedByCount "0" @default.
- W4243147628 crossrefType "journal-article" @default.
- W4243147628 hasConcept C105795698 @default.
- W4243147628 hasConcept C121332964 @default.
- W4243147628 hasConcept C132459708 @default.
- W4243147628 hasConcept C134306372 @default.
- W4243147628 hasConcept C147789679 @default.
- W4243147628 hasConcept C151376022 @default.
- W4243147628 hasConcept C185592680 @default.
- W4243147628 hasConcept C28826006 @default.
- W4243147628 hasConcept C33923547 @default.
- W4243147628 hasConcept C86183883 @default.
- W4243147628 hasConcept C95121573 @default.
- W4243147628 hasConcept C97355855 @default.
- W4243147628 hasConceptScore W4243147628C105795698 @default.
- W4243147628 hasConceptScore W4243147628C121332964 @default.
- W4243147628 hasConceptScore W4243147628C132459708 @default.
- W4243147628 hasConceptScore W4243147628C134306372 @default.
- W4243147628 hasConceptScore W4243147628C147789679 @default.
- W4243147628 hasConceptScore W4243147628C151376022 @default.
- W4243147628 hasConceptScore W4243147628C185592680 @default.
- W4243147628 hasConceptScore W4243147628C28826006 @default.
- W4243147628 hasConceptScore W4243147628C33923547 @default.
- W4243147628 hasConceptScore W4243147628C86183883 @default.
- W4243147628 hasConceptScore W4243147628C95121573 @default.
- W4243147628 hasConceptScore W4243147628C97355855 @default.
- W4243147628 hasIssue "1" @default.
- W4243147628 hasLocation W42431476281 @default.
- W4243147628 hasOpenAccess W4243147628 @default.
- W4243147628 hasPrimaryLocation W42431476281 @default.
- W4243147628 hasRelatedWork W1974546741 @default.
- W4243147628 hasRelatedWork W1990673918 @default.
- W4243147628 hasRelatedWork W1995189778 @default.
- W4243147628 hasRelatedWork W2016955159 @default.
- W4243147628 hasRelatedWork W2065322371 @default.
- W4243147628 hasRelatedWork W2065868463 @default.
- W4243147628 hasRelatedWork W2155660823 @default.
- W4243147628 hasRelatedWork W2367555855 @default.
- W4243147628 hasRelatedWork W2389614887 @default.
- W4243147628 hasRelatedWork W2997084434 @default.
- W4243147628 hasVolume "156" @default.
- W4243147628 isParatext "false" @default.
- W4243147628 isRetracted "false" @default.
- W4243147628 workType "article" @default.