Matches in SemOpenAlex for { <https://semopenalex.org/work/W4243199645> ?p ?o ?g. }
Showing items 1 to 90 of
90
with 100 items per page.
- W4243199645 endingPage "411" @default.
- W4243199645 startingPage "405" @default.
- W4243199645 abstract "At the Istituto Nazionale Tumori of Milan, a randomised adjuvant chemotherapy trial was carried out from 1982 to 1990 to compare alternating with sequential regimens of doxorubicin and CMF in 403 patients with more than 3 positive axillary nodes. Tumour proliferative activity was determined in 71% (285 cases) of women entering the clinical study. We investigated the relation between proliferative rate, determined as the [(3)H]thymidine labelling index (TLI) on tumour specimens obtained at diagnostic surgery, and clinical outcome following the 2 regimens, in which the same drugs were administered at the same dose intensity but with a different schedule. A high TLI was significantly associated with 12-year overall relapse (P = 0.009), distant metastasis (P = 0.001), and death (P = 0.002), even in the presence of information provided by tumour size, lymph node involvement, oestrogen receptors, and treatment regimen. The highest relapse-free survival (RFS) probability (45%, 95% CI 34-55%) was observed for patients with tumour TLI <5% and subjected to the sequential treatment. The lowest RFS probability (11%, 95% CI 0-26%) was observed for patients with tumour TLI >9% following the alternating regimen. Intermediate RFS probabilities, ranging from 23% to 34%, were observed for the other kinetic subgroups following the 2 treatment regimens. The benefit of sequential administration of doxorubicin and CMF was evident mainly in patients with tumours at low to intermediate proliferation." @default.
- W4243199645 created "2022-05-12" @default.
- W4243199645 creator A5023558260 @default.
- W4243199645 creator A5024845131 @default.
- W4243199645 creator A5041398398 @default.
- W4243199645 creator A5061761089 @default.
- W4243199645 creator A5082612771 @default.
- W4243199645 creator A5083493955 @default.
- W4243199645 creator A5089021391 @default.
- W4243199645 date "2000-01-01" @default.
- W4243199645 modified "2023-09-25" @default.
- W4243199645 title "Cell proliferation and outcome following doxorubicin plus CMF regimens in node-positive breast cancer" @default.
- W4243199645 cites W1262485082 @default.
- W4243199645 cites W1950270470 @default.
- W4243199645 cites W1976052438 @default.
- W4243199645 cites W1991512313 @default.
- W4243199645 cites W1995317585 @default.
- W4243199645 cites W2004236941 @default.
- W4243199645 cites W2013965516 @default.
- W4243199645 cites W2015608043 @default.
- W4243199645 cites W2050527601 @default.
- W4243199645 cites W2055481891 @default.
- W4243199645 cites W206480088 @default.
- W4243199645 cites W2080599311 @default.
- W4243199645 cites W2087050843 @default.
- W4243199645 cites W2098787760 @default.
- W4243199645 cites W2101577390 @default.
- W4243199645 cites W2129936913 @default.
- W4243199645 cites W2151088934 @default.
- W4243199645 cites W2222470382 @default.
- W4243199645 cites W2325286800 @default.
- W4243199645 cites W4249948852 @default.
- W4243199645 cites W4360754311 @default.
- W4243199645 doi "https://doi.org/10.1002/1097-0215(20000801)87:3<405::aid-ijc15>3.0.co;2-" @default.
- W4243199645 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10897047" @default.
- W4243199645 hasPublicationYear "2000" @default.
- W4243199645 type Work @default.
- W4243199645 citedByCount "20" @default.
- W4243199645 countsByYear W42431996452014 @default.
- W4243199645 countsByYear W42431996452018 @default.
- W4243199645 countsByYear W42431996452022 @default.
- W4243199645 crossrefType "journal-article" @default.
- W4243199645 hasAuthorship W4243199645A5023558260 @default.
- W4243199645 hasAuthorship W4243199645A5024845131 @default.
- W4243199645 hasAuthorship W4243199645A5041398398 @default.
- W4243199645 hasAuthorship W4243199645A5061761089 @default.
- W4243199645 hasAuthorship W4243199645A5082612771 @default.
- W4243199645 hasAuthorship W4243199645A5083493955 @default.
- W4243199645 hasAuthorship W4243199645A5089021391 @default.
- W4243199645 hasConcept C121608353 @default.
- W4243199645 hasConcept C126322002 @default.
- W4243199645 hasConcept C143998085 @default.
- W4243199645 hasConcept C2776694085 @default.
- W4243199645 hasConcept C2776802502 @default.
- W4243199645 hasConcept C2777649267 @default.
- W4243199645 hasConcept C2781303535 @default.
- W4243199645 hasConcept C2781413609 @default.
- W4243199645 hasConcept C530470458 @default.
- W4243199645 hasConcept C71924100 @default.
- W4243199645 hasConceptScore W4243199645C121608353 @default.
- W4243199645 hasConceptScore W4243199645C126322002 @default.
- W4243199645 hasConceptScore W4243199645C143998085 @default.
- W4243199645 hasConceptScore W4243199645C2776694085 @default.
- W4243199645 hasConceptScore W4243199645C2776802502 @default.
- W4243199645 hasConceptScore W4243199645C2777649267 @default.
- W4243199645 hasConceptScore W4243199645C2781303535 @default.
- W4243199645 hasConceptScore W4243199645C2781413609 @default.
- W4243199645 hasConceptScore W4243199645C530470458 @default.
- W4243199645 hasConceptScore W4243199645C71924100 @default.
- W4243199645 hasIssue "3" @default.
- W4243199645 hasLocation W42431996451 @default.
- W4243199645 hasLocation W42431996452 @default.
- W4243199645 hasOpenAccess W4243199645 @default.
- W4243199645 hasPrimaryLocation W42431996451 @default.
- W4243199645 hasRelatedWork W2020150632 @default.
- W4243199645 hasRelatedWork W2348879274 @default.
- W4243199645 hasRelatedWork W2386717267 @default.
- W4243199645 hasRelatedWork W2388730008 @default.
- W4243199645 hasRelatedWork W2591616149 @default.
- W4243199645 hasRelatedWork W2592775069 @default.
- W4243199645 hasRelatedWork W2791179561 @default.
- W4243199645 hasRelatedWork W4212973790 @default.
- W4243199645 hasRelatedWork W4367189272 @default.
- W4243199645 hasRelatedWork W757206253 @default.
- W4243199645 hasVolume "87" @default.
- W4243199645 isParatext "false" @default.
- W4243199645 isRetracted "false" @default.
- W4243199645 workType "article" @default.