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- W4243222380 abstract "Total parenteral nutrition (TPN) using glucose as nonprotein calories was associated with increases in O<sub>2</sub>consumption (V̇O<sub>2</sub>) and CO<sub>2</sub>production (V̇CO<sub>2</sub>). The magnitude of the changes was a function of the patient's clinical state and glucose load. Depleted patients showed a minimal increase in V̇O<sub>2</sub>, while V̇CO<sub>2</sub>increased 23%. Minute ventilation (V̇<sub>E</sub>) increased 32%. Hypermetabolic patients (major trauma, sepsis) had a 30% increase in VO<sub>2</sub>and a 57% increase in V̇CO<sub>2</sub>, while V̇<sub>E</sub>increased 71%. Patients with mild to moderate injuries (energy expenditure ±15% of normal) showed a 21% increase in V̇O<sub>2</sub>and a 53% increase in V̇CO<sub>2</sub>, while V̇<sub>E</sub>increased 121%. Large carbohydrate intakes were associated with increases in CO<sub>2</sub>production in all patients, while increases in O<sub>2</sub>consumption were seen primarily in hypermetabolic patients. These changes suggest that the high glucose loads of TPN may be a physiologic stress. (<i>JAMA</i>243:1444-1447, 1980)" @default.
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- W4243222380 date "1980-04-11" @default.
- W4243222380 modified "2023-10-10" @default.
- W4243222380 title "Respiratory changes induced by the large glucose loads of total parenteral nutrition" @default.
- W4243222380 doi "https://doi.org/10.1001/jama.243.14.1444" @default.
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