Matches in SemOpenAlex for { <https://semopenalex.org/work/W4243231845> ?p ?o ?g. }
Showing items 1 to 52 of
52
with 100 items per page.
- W4243231845 endingPage "942" @default.
- W4243231845 startingPage "941" @default.
- W4243231845 abstract "PHYSICIANS and members of the public understand that each new drug must, at some point, be given to humans for the first time without confident knowledge of its effects and toxic potential. Although the ethics and constraints necessary for this testing have been discussed widely, there has been little attention given specifically to the first trials of new cancer chemotherapeutic agents (phase I trials). However, new cancer chemotherapeutic agents cannot be treated simply as new drugs; their toxic effects are often so much greater than those of other drugs that the clinical investigator must weigh many conflicting arguments to justify the trial. Referring physicians, in their role as advisors, are often called on to explain the trials and to counsel patients who may enter them. Thus, they should have full appreciation of the nature and ethics of such trials. A phase I clinical trial in patients with cancer does not" @default.
- W4243231845 created "2022-05-12" @default.
- W4243231845 creator A5077659970 @default.
- W4243231845 date "1982-08-27" @default.
- W4243231845 modified "2023-09-26" @default.
- W4243231845 title "On the nature and ethics of phase I clinical trials of cancer chemotherapies" @default.
- W4243231845 doi "https://doi.org/10.1001/jama.248.8.941" @default.
- W4243231845 hasPublicationYear "1982" @default.
- W4243231845 type Work @default.
- W4243231845 citedByCount "14" @default.
- W4243231845 crossrefType "journal-article" @default.
- W4243231845 hasAuthorship W4243231845A5077659970 @default.
- W4243231845 hasConcept C121608353 @default.
- W4243231845 hasConcept C126322002 @default.
- W4243231845 hasConcept C142724271 @default.
- W4243231845 hasConcept C177713679 @default.
- W4243231845 hasConcept C204787440 @default.
- W4243231845 hasConcept C2983288658 @default.
- W4243231845 hasConcept C2992672634 @default.
- W4243231845 hasConcept C3020340455 @default.
- W4243231845 hasConcept C535046627 @default.
- W4243231845 hasConcept C71924100 @default.
- W4243231845 hasConceptScore W4243231845C121608353 @default.
- W4243231845 hasConceptScore W4243231845C126322002 @default.
- W4243231845 hasConceptScore W4243231845C142724271 @default.
- W4243231845 hasConceptScore W4243231845C177713679 @default.
- W4243231845 hasConceptScore W4243231845C204787440 @default.
- W4243231845 hasConceptScore W4243231845C2983288658 @default.
- W4243231845 hasConceptScore W4243231845C2992672634 @default.
- W4243231845 hasConceptScore W4243231845C3020340455 @default.
- W4243231845 hasConceptScore W4243231845C535046627 @default.
- W4243231845 hasConceptScore W4243231845C71924100 @default.
- W4243231845 hasIssue "8" @default.
- W4243231845 hasLocation W42432318451 @default.
- W4243231845 hasOpenAccess W4243231845 @default.
- W4243231845 hasPrimaryLocation W42432318451 @default.
- W4243231845 hasRelatedWork W198631773 @default.
- W4243231845 hasRelatedWork W2088663266 @default.
- W4243231845 hasRelatedWork W2116238555 @default.
- W4243231845 hasRelatedWork W2122311626 @default.
- W4243231845 hasRelatedWork W2135198388 @default.
- W4243231845 hasRelatedWork W2399667542 @default.
- W4243231845 hasRelatedWork W2470204250 @default.
- W4243231845 hasRelatedWork W2768515060 @default.
- W4243231845 hasRelatedWork W4200126911 @default.
- W4243231845 hasRelatedWork W4243231845 @default.
- W4243231845 hasVolume "248" @default.
- W4243231845 isParatext "false" @default.
- W4243231845 isRetracted "false" @default.
- W4243231845 workType "article" @default.