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- W4243242343 abstract "<ns4:p><ns4:bold>Background: </ns4:bold><ns4:italic>Toxoplasma gondii</ns4:italic> is an obligate, intracellular, apicomplexan parasite that causes toxoplasmosis. Although the global prevalence of toxoplasmosis has been estimated to be approximately 30%, there is limited seroprevalence data in Ghana, with a dearth of information on the impact of <ns4:italic>T. gondii</ns4:italic> on haematological parameters in exposed persons.</ns4:p><ns4:p> <ns4:bold>Methods: </ns4:bold>Questionnaires were administered to 300 consenting individuals to obtain demographic information and assessment of their risk of exposure to <ns4:italic>T. gondii</ns4:italic>. Using anti-<ns4:italic>T. gondii </ns4:italic>IgG/IgM combo test kits, seropositivity to parasite-specific IgG and/or IgM was determined. A haematological analyser was used to measure haematological parameters.</ns4:p><ns4:p> <ns4:bold>Results: </ns4:bold>The participants included 58 males and 242 females, and ranged in age from 6 months to 84 years, with a median age of 27 years. There was an overall seroprevalence of 50.3% (n=151), with 49.7% (n=149) of the study participants seropositive for IgG and 1% (n=3) testing positive for IgM. Furthermore, the observed seroprevalence among pregnant women was 56.4% (n=62). With regards to the different communities in which the hospitals were located, a seroprevalence of 55.6% was observed in the rural community, 50.6% in the peri-urban community and 47.1% in the urban community. The study identified cat ownership, contact with cat litter [RR (95% CI: 1.76 (1.23-2.53), 1.66 (1.03-2.67), 1.25(1.00-1.57)] and age (p<0.001) as risk factors for infection. Analyses of haematological data also revealed significant differences between the red blood cell counts (p=0.038) and mean corpuscular volumes (p=0.0007) of seropositive and seronegative study participants.</ns4:p><ns4:p> <ns4:bold>Conclusions:</ns4:bold> About half of the study population, including a significant number of women of reproductive age carried antibodies against <ns4:italic>T. gondii</ns4:italic>, raising questions about the risk of congenital toxoplasmosis, as well as possible links to anaemia. We, therefore, recommend that screening for <ns4:italic>Toxoplasma gondii </ns4:italic>be included in the routine screening of pregnant women seeking antenatal care.</ns4:p>" @default.
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- W4243242343 date "2019-11-26" @default.
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- W4243242343 title "Seroprevalence, risk factors and impact of Toxoplasma gondii infection on haematological parameters in the Ashanti region of Ghana: a cross-sectional study" @default.
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- W4243242343 doi "https://doi.org/10.12688/aasopenres.13022.1" @default.
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