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- W4243260475 abstract "This chapter presents studies on drugs that act on cerebral and peripheral circulations. The phosphodiesterase inhibitor cilostazol has antiplatelet properties in addition to an action on vascular smooth muscle and was therefore initially thought to be unsafe in combination with other commonly used antiplatelet drugs, such as aspirin or clopidogrel. In a crossover study in 21 patients with peripheral disease, cilostazol did not significantly increase bleeding time, nor further prolong it when it was added to any regimen containing aspirin or clopidogrel. Thus, cilostazol is not expected to increase the risk of adverse bleeding effects when combined with aspirin or clopidogrel. In another study, calcium dobesilate ranked second in a list of drugs associated with agranulocytosis. Reviews of inhibitors of phosphodiesterase type V repeatedly stress the overall good tolerance of this class of drugs. The most common complaints are headache, facial flushing, nasal congestion, and dyspepsia. Prolonged erection and priapism are rare. There is a risk of hypotension when the triptans are combined with nitrates." @default.
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- W4243260475 date "2008-01-01" @default.
- W4243260475 modified "2023-09-27" @default.
- W4243260475 title "Drugs acting on the cerebral and peripheral circulations" @default.
- W4243260475 doi "https://doi.org/10.1016/s0378-6080(08)00019-6" @default.
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