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- W4243272333 abstract "Optical cross-reactive sensor arrays (the so-called chemical “noses/tongues”) have recently been demonstrated as a powerful tool for high-throughput protein detecting and analysis. Nevertheless, applying this technology to biomarker detection is complicated by the difficulty of non-selective sensors to operate in biological mixtures. Herein we demonstrate a step toward circumventing this limitation by using self-assembled fluorescent receptors consisting of two distinct recognition motifs: specific and non-specific. When combined in an array, binding cooperatively between the specific and non-specific protein binders enables the system to discriminate among closely related isoform biomarkers even in the presence of serum proteins or within human urine." @default.
- W4243272333 created "2022-05-12" @default.
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- W4243272333 date "2014-05-19" @default.
- W4243272333 modified "2023-09-25" @default.
- W4243272333 title "Targeted Protein Surface Sensors as a Tool for Analyzing Small Populations of Proteins in Biological Mixtures" @default.
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- W4243272333 doi "https://doi.org/10.1002/ange.201402501" @default.
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