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- W4243313372 abstract "326 Over the past eleven years, the transplant centers in our OPO have successfully transplanted A2 and A2B (A2/A2B) kidneys into B and O patients. Based on our experience, in September, 1991, we implemented an OPO-wide, UNOS approved cadaver kidney allocation variance that allows us to allocate A2/A2B kidneys first to B, or only A2 kidneys to O patients, all of whom have low anti-A (natural isoagglutinin) IgG titers (≤ 4). The variance also stipulates that only B and O patients who have quarterly anti-A IgG titers done are eligible to receive A2/A2B kidneys. During the 6-year period from September, 1991 to October, 1997, we transplanted 27 A2 (90%) and 3 A2B (10%) kidneys into 19 B(63%) and 11 O (37%) patients. Of the 76 cadaveric kidneys transplanted into blood group B recipients during this time, 25% (19/76) were from A2 or A2B donors. In 1997 alone, 44% (11/25) of the cadaveric renal transplants into blood group B recipients were from A2 or A2B donors. Our one-month function rate is 96% (29/30) and three-year graft survival for these B and O patients is 80%, which is not significantly different from that of our ABO-compatible transplants (85%; n=749)(log-rank=0.5; DWFG censored) performed concurrently. Finally, we recently started molecular ABO genotyping by PCR-SSP. The data in the following table shows a comparison of ABO serotypes with ABO PCR-SSP genotypes for patients and donors. In summary, these data show that the transplantation rate of the blood group B waiting list can be successfully increased by using kidneys from A2 or A2B donors. Over this 6-year period, 25% of our B waiting list candidates received A2 or A2B kidneys, thus increasing by that amount the access of B waiting list candidates to donor kidneys. The use of molecular ABO genotyping (PCR-SSP) is an adjunct to ABO serotyping for laboratory confirmation of the A2 donor." @default.
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- W4243313372 date "1998-06-01" @default.
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- W4243313372 title "TRANSPLANTATION RATE OF THE BLOOD GROUP B WAITING LIST IS INCREASED BY USING A2 and A2B KIDNEYS" @default.
- W4243313372 doi "https://doi.org/10.1097/00007890-199806270-00345" @default.
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