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- W4243359478 abstract "The occurrence of carbamoylphosphate in higher plants and animals has excited little interest as yet. There are two carbamoylphosphate (CAP) synthetases responsible for the synthesis in vertebrates. CAP synthetase I is located in high activity in the liver of adult urea-forming vertebrates; it provides CAP for the synthesis of urea. This enzyme is not rate-limiting in the biosynthesis of urea and it is possible that free CAP occurs in liver cells. CAP synthetase II is found in the soluble fraction of the tissues of many vertebrates and it is responsible for the synthesis of CAP for the biosynthesis of pyrimidines. The latter enzyme is probably rate-limiting in the biosynthesis of pyrimidines; the enzyme activity in tissues is low. It is, therefore, unlikely that free carbamoylphosphate occurs in the extra-hepatic tissues of normal animals. CAP is not found in the blood of normal rabbits. CAP can be determined specifically and quantitatively by the enzymatic synthesis of citrulline or carbamoylaspartate if highly purified ornithine transcarbamoylase or aspartate transcarbamoylase is used. The use of radioactively labeled L -ornithine or L -aspartate considerably increases the sensitivity of the method. This chapter provides an overview of the enzymatic method used for determining CAP." @default.
- W4243359478 created "2022-05-12" @default.
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- W4243359478 date "1974-01-01" @default.
- W4243359478 modified "2023-09-25" @default.
- W4243359478 title "Carbamoylphosphate" @default.
- W4243359478 doi "https://doi.org/10.1016/b978-0-12-091304-6.50025-2" @default.
- W4243359478 hasPublicationYear "1974" @default.
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