Matches in SemOpenAlex for { <https://semopenalex.org/work/W4243361312> ?p ?o ?g. }
Showing items 1 to 65 of
65
with 100 items per page.
- W4243361312 abstract "Abstract Despite having remarkable utility in treating movement disorders, the lack of understanding of the underlying mechanisms of high-frequency deep brain stimulation (DBS) is a main challenge in choosing personalized stimulation parameters. Here we investigate the modulations in local field potentials induced by therapeutic and non-therapeutic electrical stimulation of the subthalamic nucleus (STN) in Parkinson’s disease patients undergoing DBS surgery. We find that therapeutic high-frequency stimulation (130-180 Hz) induces high-frequency oscillations (~300 Hz, HFO) similar to those observed with pharmacological treatment. Along with HFOs, we also observed evoked compound activity (ECA) after each stimulation pulse. While ECA was observed in both therapeutic and non-therapeutic (20Hz) stimulation, the HFOs were induced only with therapeutic frequencies and the associated ECA were significantly more resonant. The relative degree of enhancement in the HFO power was related to the interaction of stimulation pulse with the phase of ECA.We propose that high-frequency STN-DBS tunes the neural oscillations to their healthy/treated state, similar to pharmacological treatment, and the stimulation frequency to maximize these oscillations can be inferred from the phase of ECA waveforms of individual subjects. The induced HFOs can, therefore, be utilized as a marker of successful re-calibration of the dysfunctional circuit generating PD symptoms." @default.
- W4243361312 created "2022-05-12" @default.
- W4243361312 creator A5007415393 @default.
- W4243361312 creator A5009198401 @default.
- W4243361312 creator A5079501073 @default.
- W4243361312 creator A5082661128 @default.
- W4243361312 date "2020-10-08" @default.
- W4243361312 modified "2023-10-12" @default.
- W4243361312 title "Electroceutically induced subthalamic high frequency oscillations and evoked compound activity may explain the mechanism of therapeutic stimulation in Parkinson's Disease" @default.
- W4243361312 doi "https://doi.org/10.21203/rs.3.rs-63781/v1" @default.
- W4243361312 hasPublicationYear "2020" @default.
- W4243361312 type Work @default.
- W4243361312 citedByCount "0" @default.
- W4243361312 crossrefType "posted-content" @default.
- W4243361312 hasAuthorship W4243361312A5007415393 @default.
- W4243361312 hasAuthorship W4243361312A5009198401 @default.
- W4243361312 hasAuthorship W4243361312A5079501073 @default.
- W4243361312 hasAuthorship W4243361312A5082661128 @default.
- W4243361312 hasBestOaLocation W42433613121 @default.
- W4243361312 hasConcept C102652120 @default.
- W4243361312 hasConcept C117838684 @default.
- W4243361312 hasConcept C120665830 @default.
- W4243361312 hasConcept C121332964 @default.
- W4243361312 hasConcept C126322002 @default.
- W4243361312 hasConcept C15744967 @default.
- W4243361312 hasConcept C169760540 @default.
- W4243361312 hasConcept C24998067 @default.
- W4243361312 hasConcept C2777319143 @default.
- W4243361312 hasConcept C2778542668 @default.
- W4243361312 hasConcept C2779134260 @default.
- W4243361312 hasConcept C2779734285 @default.
- W4243361312 hasConcept C2780167933 @default.
- W4243361312 hasConcept C71924100 @default.
- W4243361312 hasConcept C94915269 @default.
- W4243361312 hasConceptScore W4243361312C102652120 @default.
- W4243361312 hasConceptScore W4243361312C117838684 @default.
- W4243361312 hasConceptScore W4243361312C120665830 @default.
- W4243361312 hasConceptScore W4243361312C121332964 @default.
- W4243361312 hasConceptScore W4243361312C126322002 @default.
- W4243361312 hasConceptScore W4243361312C15744967 @default.
- W4243361312 hasConceptScore W4243361312C169760540 @default.
- W4243361312 hasConceptScore W4243361312C24998067 @default.
- W4243361312 hasConceptScore W4243361312C2777319143 @default.
- W4243361312 hasConceptScore W4243361312C2778542668 @default.
- W4243361312 hasConceptScore W4243361312C2779134260 @default.
- W4243361312 hasConceptScore W4243361312C2779734285 @default.
- W4243361312 hasConceptScore W4243361312C2780167933 @default.
- W4243361312 hasConceptScore W4243361312C71924100 @default.
- W4243361312 hasConceptScore W4243361312C94915269 @default.
- W4243361312 hasLocation W42433613121 @default.
- W4243361312 hasOpenAccess W4243361312 @default.
- W4243361312 hasPrimaryLocation W42433613121 @default.
- W4243361312 hasRelatedWork W10135252 @default.
- W4243361312 hasRelatedWork W12794346 @default.
- W4243361312 hasRelatedWork W13541480 @default.
- W4243361312 hasRelatedWork W2231892 @default.
- W4243361312 hasRelatedWork W4382825 @default.
- W4243361312 hasRelatedWork W5786955 @default.
- W4243361312 hasRelatedWork W6758148 @default.
- W4243361312 hasRelatedWork W7693309 @default.
- W4243361312 hasRelatedWork W9965294 @default.
- W4243361312 hasRelatedWork W9854617 @default.
- W4243361312 isParatext "false" @default.
- W4243361312 isRetracted "false" @default.
- W4243361312 workType "article" @default.