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- W4243362375 abstract "Abstract Background: Limited data focused the transition from metabolically healthy to metabolic abnormalities on future risk of developing carotid artery plaque (CAP). We aimed to evaluate the association between the shift of metabolic status and future risk of CAP in community-based Chinese adults. Methods: Blood pressure, fasting blood glucose, glycated hemoglobin A1c, lipid profiles, and carotid artery B ultrasonography were annually assessed throughout the study. Metabolically healthy were defined as participants without history of metabolic diseases and cancer but with normal value of aforementioned parameters at baseline (2013). If any of these parameters became abnormal during follow up, it was considered as the transition. Results : Included were 9,836 Chinese adults (4,085 males and 5,751 females) who were metabolically healthy at baseline aged 35.8±9.0 years. The most two common types of metabolic abnormalities during five years of follow up was high blood pressure (cumulative proportion: 36.4%) and impaired glucose regulation (20.1%). We have identified 133 incident cases of CAP during follow up. Compared to those who remained metabolically healthy, the transition to high blood pressure, high total cholesterol, high low-density lipoprotein cholesterols, or dyslipidemia was associated with high risk of developing carotid artery plaque (Hazards ratios (HRs) ranged from 1.69 to 2.34; p<0.05 for all). The transition to impaired glucose regulation, high total triglycerides, and low high-density lipoprotein cholesterols, was associated with high risk of carotid artery plaque only in participants with metabolically healthy overweight at baseline (HR ranged from 1.95 to 4.62; p <0.05 for all). Conclusions : The transition from baseline metabolically healthy to metabolic abnormalities, was associated with high risk of incident carotid artery plaque." @default.
- W4243362375 created "2022-05-12" @default.
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- W4243362375 date "2020-10-15" @default.
- W4243362375 modified "2023-09-26" @default.
- W4243362375 title "Transition from Metabolically Healthy to Unhealthy Associated with Risk of Carotid Artery Plaque in Chinese Adults" @default.
- W4243362375 doi "https://doi.org/10.21203/rs.3.rs-91098/v1" @default.
- W4243362375 hasPublicationYear "2020" @default.
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