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- W4243365551 abstract "Various types of injury including mechanical transection, ischemia and compression result in axonal degeneration. The classical type is the Wallerian degeneration after experimental nerve transection and the structural alterations observed in the nerve distal to the injury occur also in a variety of pathological states. The degeneration starts at a single point and finally involves the entire axon distal of the injured part. This process is referred to as anterograde (Wallerian) degeneration. The one involving the part of the axon proximal to the injury is called retrograde degeneration. The structural changes follow a certain time course and develop gradually. Initially, axon swelling and disintegration of neurofilaments and microtubules occurs. The axolemma becomes discontinuous, and retraction and disintegration of myelin ensues. These changes result in the progressive disintegration of the axon and myelin. Fragments of the axon often contain large amounts of myelin debris and are called myelin ovoid. Schwarmcells proliferate and ingest the degenerating axon." @default.
- W4243365551 created "2022-05-12" @default.
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- W4243365551 date "2010-01-01" @default.
- W4243365551 modified "2023-09-30" @default.
- W4243365551 title "Axonal Degeneration" @default.
- W4243365551 cites W2076818528 @default.
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- W4243365551 doi "https://doi.org/10.1007/978-3-211-99390-3_169" @default.
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