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• W4243379165 abstract "N1-methyladenosine (m1A) is a prevalent and reversible RNA modification, which plays a crucial role in the regulation of RNA fate and gene expression. However, the lack of tools to precisely manipulate m1A sites in specific transcripts has hindered efforts to clarify the association between a specific m1A-modified transcript and its phenotypic outcomes. Here we develop a CRISPR-Cas13d-based tool called reengineered m1A modification valid eraser (termed “REMOVER”) for targeted m1A demethylation of a specific transcript. The catalytically inactive RfxCas13d (dCasRx) is fused to the m1A demethylase ALKBH3, and the dCasRx-ALKBH3 fusion protein can mediate potent demethylation of m1A-modified RNAs. We further find that REMOVER can specifically demethylate m1A of MALAT1 and PRUNE1 RNAs, thereby significantly increasing their stability. Our study establishes REMOVER as a tool for targeted RNA demethylation of specific m1A-modified transcripts, which enables further elucidation of the relationship between m1A modification of specific transcripts and their phenotypic outcomes." @default.
• W4243379165 created "2022-05-12" @default.
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• W4243379165 date "2021-06-27" @default.
• W4243379165 modified "2023-10-18" @default.
• W4243379165 title "Programmable RNA <i>N</i> ¹ ‐Methyladenosine Demethylation by a Cas13d‐Directed Demethylase" @default.
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• W4243379165 doi "https://doi.org/10.1002/ange.202105253" @default.
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