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- W4243430627 abstract "Infantile spasms constitute both a distinctive seizure type and an age-specific epilepsy syndrome that have been extensively described for over a century. Standardization of the classification of infantile spasms has evolved, culminating in recent recommendations for separately recognizing and distinguishing the seizure type (spasms or epileptic spasms) and the epilepsy syndrome of infantile spasms (West syndrome). More-detailed descriptions of the clinical and electrographic features of epileptic spasms and hypsarrhythmia have emerged. Advances in neuroimaging techniques have revealed clues about pathophysiology and increased the etiologic yield of the diagnostic evaluation of patients with infantile spasms. Adrenocorticotrophic hormone remains the treatment of choice for many neurologists. Recent controlled studies support vigabatrin as first-line therapy, and open-label studies suggest that topiramate, lamotrigine, and zonisamide may be useful in treating spasms. Recent reports of visual-field constriction with vigabatrin may limit its use. Surgical treatment has been used successfully in a select subgroup of patients with secondarily generalized spasms from a single epileptogenic zone. Although the prognosis for most patients with infantile spasms remains poor, further studies identifying predictors of favorable prognosis and recent advances in understanding the pathophysiology of infantile spasms offer hope of safer and more-effective therapies that improve long-term outcome." @default.
- W4243430627 created "2022-05-12" @default.
- W4243430627 creator A5058587345 @default.
- W4243430627 creator A5074208804 @default.
- W4243430627 date "2001-02-01" @default.
- W4243430627 modified "2023-10-18" @default.
- W4243430627 title "Infantile spasms" @default.
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- W4243430627 doi "https://doi.org/10.1016/s0887-8994(00)00238-1" @default.
- W4243430627 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11275456" @default.
- W4243430627 hasPublicationYear "2001" @default.
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