Matches in SemOpenAlex for { <https://semopenalex.org/work/W4243458619> ?p ?o ?g. }
- W4243458619 endingPage "3694" @default.
- W4243458619 startingPage "3683" @default.
- W4243458619 abstract "Transforming growth factor beta (TGF-beta) is a potent inhibitor of epithelial cell growth. Cyclins E and A in association with Cdk2 have been shown to play a role in the G1-to-S phase transition in mammalian cells. We have studied the effects of TGF-beta-mediated growth arrest on G1/S cyclins E and A. Inhibition of cyclin A-associated kinase by TGF-beta is primarily due to a decrease in cyclin A mRNA and protein. By contrast, while TGF-beta inhibits accumulation of cyclin E mRNA, the reduction in cyclin E protein is minimal. Instead, we find that the activation of cyclin E-associated kinase that normally accompanies the G1-to-S phase transition is inhibited. A novel inhibitor of cyclin-Cdk complexes was detected in TGF-beta-treated cell lysates. Inhibition is mediated by a heat-stable protein that targets both Cdk2 and Cdc2 kinases. In G0-arrested cells, a similar inhibitor of Cdk2 kinase was detected. These data suggest the existence of an inhibitor of cyclin-dependent kinases induced under different conditions to mediate antiproliferative responses." @default.
- W4243458619 created "2022-05-12" @default.
- W4243458619 creator A5008688636 @default.
- W4243458619 creator A5033542763 @default.
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- W4243458619 creator A5060303266 @default.
- W4243458619 creator A5063410376 @default.
- W4243458619 creator A5077626637 @default.
- W4243458619 date "1994-06-01" @default.
- W4243458619 modified "2023-09-27" @default.
- W4243458619 title "A novel inhibitor of cyclin-Cdk activity detected in transforming growth factor beta-arrested epithelial cells" @default.
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