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- W4243471489 abstract "In vitro studies and animal experiments suggest that the production of 1,25-dihydroxyvitamin D[ 1,25-(OH)2D] and 24,25-(OH)2D is reciprocally controlled by 1,25-(OH)2D. To investigate the role of the vitamin D receptor (VDR) in controlling vitamin D metabolism in humans, we studied 10 patients with vitamin D-dependent rickets type II due to a defective VDR. After a period of high dose calcium therapy, 7 of the patients had normal serum calcium, phosphorus, alkaline phosphatase, and plasma PTH levels (PTH-N), and 3 showed increased serum alkaline phosphatase and plasma PTH (PTH-H). Serum calcium, phosphorus, alkaline phosphatase, PTH, vitamin D metabolites, urinary calcium/creatinine, and renal phosphate threshold concentration were compared with unaffected family members that comprised the control group. Vitamin D metabolites were measured before and after an oral load of 50,000 U/m2 cholecalciferol. Compared with the control group, 1,25-(OH)2D levels were significantly higher and 24,25-(OH)2D levels were lower in the PTH-N group and even more so in the PTH-H group. 1α-Hydroxylase (1-OHase) and 24-OHase activities were estimated by the product/substrate ratio. In the PTH-N group, 1-OHase activity was higher and 24-OHase activity was lower than in controls. In the PTH-H group, 1-OHase activity was even higher, probably due to an additive effect of PTH. Thus, 1,25-(OH)2D-liganded VDR is a major control mechanism for vitamin D metabolism, and PTH exerts an additive effect. Assessment of the influence of 1,25-(OH)2D shows reciprocal control of enzyme activity in man, suppressing 1-OHase and stimulating 24-OHase activity." @default.
- W4243471489 created "2022-05-12" @default.
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- W4243471489 date "2001-05-01" @default.
- W4243471489 modified "2023-10-17" @default.
- W4243471489 title "The Role of the Vitamin D Receptor in Regulating Vitamin D Metabolism: A Study of Vitamin D-Dependent Rickets, Type II" @default.
- W4243471489 doi "https://doi.org/10.1210/jc.86.5.1908" @default.
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