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- W4243534680 abstract "Abstract Perception of aversive sensory stimuli such as pain and innate threat cues is essential for animal survival. The amygdala is critical for aversive sensory perception, and it has been suggested that multiple parallel pathways independently relay aversive cues from each sensory modality to the amygdala. However, a convergent pathway that relays multisensory aversive cues to the amygdala has not been identified. Here, we report that neurons expressing calcitonin gene-related peptide (CGRP) in the parvocellular subparafasicular thalamic nucleus (SPFp) are necessary and sufficient for affective-motivational pain perception by forming a spino-thalamo-amygdaloid pain pathway. In addition, we find that this thalamic CGRP pain pathway, together with well-known parabrachio-amygdaloid CGRP pain pathway, is critical for the perception of multisensory innate threat cues. The discovery of unified pathways that collectively gate aversive sensory stimuli from all sensory modalities may provide critical circuit-based insights for developing therapeutic interventions for affective pain- and innate fear-related disorders." @default.
- W4243534680 created "2022-05-12" @default.
- W4243534680 creator A5004190844 @default.
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- W4243534680 creator A5090823484 @default.
- W4243534680 date "2020-11-18" @default.
- W4243534680 modified "2023-10-18" @default.
- W4243534680 title "Unified neural pathways that gate affective pain and multisensory innate threat signals to the amygdala" @default.
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