FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4243549693> ?p ?o ?g. }

• W4243549693 abstract "Mannitol is an osmotic agent and a free radical scavenger so it might decrease oedema and tissue damage in stroke.To test whether treatment with mannitol reduces short and long-term case fatality and dependency after acute ischaemic stroke or cerebral parenchymal haemorrhage.We searched the Cochrane Stroke Group Specialised Trials Register. In addition to this, supplementary MEDLINE searches were performed. The Chinese Stroke Trials Register was checked and the Latin-American databank LILACS was searched with the search term MANNITOL and its variations in the Portuguese and Spanish languages. A search was performed of Masters and Ph.D. degree theses in the databank of Sao Paulo University, and in abstracts of medical congresses on neurology and neurosurgery from 1965 to 1997 in Brazil.Truly randomised unconfounded clinical trials comparing the effect of mannitol with placebo or open control in patients with acute ischaemic stroke or parenchymal haemorrhage were eligible for inclusion.Two reviewers independently selected the trials to be included in the review. After reaching an agreement on which trials to include, two of the reviewers extracted data from the trials and performed the data analysis. Accuracy of data extraction was checked by comparing the results. Included trials were tabulated for methodological quality including the method of randomisation and blinding, and stating if CT was performed, if patients were lost to follow-up and if intention-to-treat analysis was performed. Data synthesis and analysis was performed using the Cochrane Review Manager software.Only one trial fulfilled the inclusion criteria. The number of included patients was small (36 treated and 41 controls) and the follow up was short. Neither beneficial nor harmful effects of mannitol could be proved. Case fatality, the proportion of dependent patients at the end of the follow up and side effects were not reported and were not available from the investigators. The planned outcome analyses and sensitivity analyses could not be performed due to lack of appropriate trials.There is currently not enough evidence to decide whether the routine use of mannitol in acute stroke would result in any beneficial or harmful effect. The routine use of mannitol in all patients with acute stroke is not supported by any evidence from randomised controlled clinical trials. Further trials are needed to confirm or refute the routine use of mannitol in acute stroke." @default.
• W4243549693 created "2022-05-12" @default.
• W4243549693 creator A5011947448 @default.
• W4243549693 creator A5037708672 @default.
• W4243549693 creator A5070631822 @default.
• W4243549693 creator A5090331551 @default.
• W4243549693 date "2001-01-22" @default.
• W4243549693 modified "2023-10-02" @default.
• W4243549693 title "Mannitol for acute stroke" @default.
• W4243549693 cites W122950182 @default.
• W4243549693 cites W1498265361 @default.
• W4243549693 cites W186378411 @default.
• W4243549693 cites W1967684027 @default.
• W4243549693 cites W1992302964 @default.
• W4243549693 cites W1994504422 @default.
• W4243549693 cites W1996649175 @default.
• W4243549693 cites W2011793103 @default.
• W4243549693 cites W2015075820 @default.
• W4243549693 cites W2016169463 @default.
• W4243549693 cites W2021325630 @default.
• W4243549693 cites W2026458612 @default.
• W4243549693 cites W2029165230 @default.
• W4243549693 cites W2036954890 @default.
• W4243549693 cites W2040785596 @default.
• W4243549693 cites W2042013119 @default.
• W4243549693 cites W2042947748 @default.
• W4243549693 cites W2044267185 @default.
• W4243549693 cites W2073274865 @default.
• W4243549693 cites W2075946336 @default.
• W4243549693 cites W2077672662 @default.
• W4243549693 cites W2079665140 @default.
• W4243549693 cites W2085518651 @default.
• W4243549693 cites W2101259186 @default.
• W4243549693 cites W2104534907 @default.
• W4243549693 cites W2109411133 @default.
• W4243549693 cites W2116522716 @default.
• W4243549693 cites W2136392104 @default.
• W4243549693 cites W2136876490 @default.
• W4243549693 cites W2143531222 @default.
• W4243549693 cites W2146238710 @default.
• W4243549693 cites W2151327193 @default.
• W4243549693 cites W2152639703 @default.
• W4243549693 cites W2159419498 @default.
• W4243549693 cites W2335414731 @default.
• W4243549693 cites W2464177285 @default.
• W4243549693 cites W4205999951 @default.
• W4243549693 cites W4243000051 @default.
• W4243549693 doi "https://doi.org/10.1002/14651858.cd001153" @default.
• W4243549693 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11279707" @default.
• W4243549693 hasPublicationYear "2001" @default.
• W4243549693 type Work @default.
• W4243549693 citedByCount "20" @default.
• W4243549693 countsByYear W42435496932013 @default.
• W4243549693 countsByYear W42435496932014 @default.
• W4243549693 countsByYear W42435496932019 @default.
• W4243549693 countsByYear W42435496932022 @default.
• W4243549693 crossrefType "reference-entry" @default.
• W4243549693 hasAuthorship W4243549693A5011947448 @default.
• W4243549693 hasAuthorship W4243549693A5037708672 @default.
• W4243549693 hasAuthorship W4243549693A5070631822 @default.
• W4243549693 hasAuthorship W4243549693A5090331551 @default.
• W4243549693 hasConcept C126322002 @default.
• W4243549693 hasConcept C127413603 @default.
• W4243549693 hasConcept C136524200 @default.
• W4243549693 hasConcept C142724271 @default.
• W4243549693 hasConcept C17744445 @default.
• W4243549693 hasConcept C1862650 @default.
• W4243549693 hasConcept C199539241 @default.
• W4243549693 hasConcept C204787440 @default.
• W4243549693 hasConcept C27081682 @default.
• W4243549693 hasConcept C2771230 @default.
• W4243549693 hasConcept C2776478404 @default.
• W4243549693 hasConcept C2779473830 @default.
• W4243549693 hasConcept C2780645631 @default.
• W4243549693 hasConcept C535046627 @default.
• W4243549693 hasConcept C71924100 @default.
• W4243549693 hasConcept C78519656 @default.
• W4243549693 hasConcept C95190672 @default.
• W4243549693 hasConceptScore W4243549693C126322002 @default.
• W4243549693 hasConceptScore W4243549693C127413603 @default.
• W4243549693 hasConceptScore W4243549693C136524200 @default.
• W4243549693 hasConceptScore W4243549693C142724271 @default.
• W4243549693 hasConceptScore W4243549693C17744445 @default.
• W4243549693 hasConceptScore W4243549693C1862650 @default.
• W4243549693 hasConceptScore W4243549693C199539241 @default.
• W4243549693 hasConceptScore W4243549693C204787440 @default.
• W4243549693 hasConceptScore W4243549693C27081682 @default.
• W4243549693 hasConceptScore W4243549693C2771230 @default.
• W4243549693 hasConceptScore W4243549693C2776478404 @default.
• W4243549693 hasConceptScore W4243549693C2779473830 @default.
• W4243549693 hasConceptScore W4243549693C2780645631 @default.
• W4243549693 hasConceptScore W4243549693C535046627 @default.
• W4243549693 hasConceptScore W4243549693C71924100 @default.
• W4243549693 hasConceptScore W4243549693C78519656 @default.
• W4243549693 hasConceptScore W4243549693C95190672 @default.
• W4243549693 hasLocation W42435496931 @default.
• W4243549693 hasLocation W42435496932 @default.
• W4243549693 hasOpenAccess W4243549693 @default.
• W4243549693 hasPrimaryLocation W42435496931 @default.
• W4243549693 hasRelatedWork W1576132118 @default.

• next