FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4243562172> ?p ?o ?g. }

• W4243562172 endingPage "4402" @default.
• W4243562172 startingPage "4394" @default.
• W4243562172 abstract "Thrombopoietin (Tpo) has proliferative and maturational effects on immature and more committed cells, respectively. We previously reported a role for Tpo as a survival factor in the factor-dependent human cell line M07e by demonstrating that Tpo suppresses apoptosis in the absence of induced proliferation. Wild-type p53 is a tumor suppressor gene that can play a vital role in mediating growth factor withdrawal-induced apoptosis in factor-dependent hematopoietic cells. Wild-type p53 can switch from a suppressor conformation, with an antiproliferative, pro-apoptotic phenotype, to a promoter conformation that has a diminished ability to mediate cell cycle arrest and apoptosis. In an effort to elucidate the mechanisms through which Tpo suppresses apoptosis, we investigated the effects of Tpo treatment on p53-mediated apoptosis in M07e cells. Tpo upregulated the expression of the promoter conformation of p53 in M07e cells coincident with a downregulation of Bax and Mdm2 protein levels. Protein levels of Bcl-2 and Bcl-xL did not significantly vary as a function of growth-factor stimulation. Conversely, the levels of suppressor conformation p53 were maximal when M07e was in a growth arrested state and decreased during factor stimulation. Furthermore, Tpo treatment induced an extranuclear buildup and greatly weakened the DNA binding capacity of p53. p53-specific antisense oligonucleotide treatment recapitulated the effects of Tpo treatment on the levels of Bax, Mdm-2, and Bcl-2. These results suggest that Tpo is suppressing growth factor withdrawal induced-apoptosis, at least in part, by downregulating the expression of pro-apoptotic Bax protein levels, through modulating the conformation of p53, which results in a functional inactivation of its pro-apoptotic abilities." @default.
• W4243562172 created "2022-05-12" @default.
• W4243562172 creator A5001318652 @default.
• W4243562172 creator A5026325168 @default.
• W4243562172 creator A5038161052 @default.
• W4243562172 creator A5063687138 @default.
• W4243562172 creator A5069031914 @default.
• W4243562172 date "1997-12-01" @default.
• W4243562172 modified "2023-10-01" @default.
• W4243562172 title "Thrombopoietin Upregulates the Promoter Conformation of p53 in a Proliferation-Independent Manner Coincident With a Decreased Expression of Bax: Potential Mechanisms for Survival Enhancing Effects" @default.
• W4243562172 cites W138285015 @default.
• W4243562172 cites W1501273614 @default.
• W4243562172 cites W1522731616 @default.
• W4243562172 cites W1545495395 @default.
• W4243562172 cites W1665387657 @default.
• W4243562172 cites W189385581 @default.
• W4243562172 cites W1970611929 @default.
• W4243562172 cites W1970839214 @default.
• W4243562172 cites W1981345152 @default.
• W4243562172 cites W1986179131 @default.
• W4243562172 cites W1988754122 @default.
• W4243562172 cites W1991736202 @default.
• W4243562172 cites W1997942538 @default.
• W4243562172 cites W2015274522 @default.
• W4243562172 cites W2015519364 @default.
• W4243562172 cites W2038377343 @default.
• W4243562172 cites W2045086385 @default.
• W4243562172 cites W2049808548 @default.
• W4243562172 cites W2053422110 @default.
• W4243562172 cites W2062252787 @default.
• W4243562172 cites W2063176993 @default.
• W4243562172 cites W2064441863 @default.
• W4243562172 cites W2074114480 @default.
• W4243562172 cites W2077047827 @default.
• W4243562172 cites W2095159309 @default.
• W4243562172 cites W2099907467 @default.
• W4243562172 cites W2103818290 @default.
• W4243562172 cites W2108172661 @default.
• W4243562172 cites W2118443752 @default.
• W4243562172 cites W2125236386 @default.
• W4243562172 cites W2129820223 @default.
• W4243562172 cites W2134979684 @default.
• W4243562172 cites W2147043754 @default.
• W4243562172 cites W2148142571 @default.
• W4243562172 cites W2245199534 @default.
• W4243562172 cites W226299187 @default.
• W4243562172 cites W2266255187 @default.
• W4243562172 cites W2338263125 @default.
• W4243562172 cites W3110939446 @default.
• W4243562172 cites W4244105110 @default.
• W4243562172 cites W4255221429 @default.
• W4243562172 cites W431848726 @default.
• W4243562172 doi "https://doi.org/10.1182/blood.v90.11.4394.4394_4394_4402" @default.
• W4243562172 hasPublicationYear "1997" @default.
• W4243562172 type Work @default.
• W4243562172 citedByCount "1" @default.
• W4243562172 crossrefType "journal-article" @default.
• W4243562172 hasAuthorship W4243562172A5001318652 @default.
• W4243562172 hasAuthorship W4243562172A5026325168 @default.
• W4243562172 hasAuthorship W4243562172A5038161052 @default.
• W4243562172 hasAuthorship W4243562172A5063687138 @default.
• W4243562172 hasAuthorship W4243562172A5069031914 @default.
• W4243562172 hasBestOaLocation W42435621721 @default.
• W4243562172 hasConcept C104317684 @default.
• W4243562172 hasConcept C109159458 @default.
• W4243562172 hasConcept C12519072 @default.
• W4243562172 hasConcept C127561419 @default.
• W4243562172 hasConcept C153911025 @default.
• W4243562172 hasConcept C170493617 @default.
• W4243562172 hasConcept C190283241 @default.
• W4243562172 hasConcept C2775960820 @default.
• W4243562172 hasConcept C2777863708 @default.
• W4243562172 hasConcept C2780362710 @default.
• W4243562172 hasConcept C28328180 @default.
• W4243562172 hasConcept C31573885 @default.
• W4243562172 hasConcept C502942594 @default.
• W4243562172 hasConcept C54355233 @default.
• W4243562172 hasConcept C86803240 @default.
• W4243562172 hasConcept C95444343 @default.
• W4243562172 hasConceptScore W4243562172C104317684 @default.
• W4243562172 hasConceptScore W4243562172C109159458 @default.
• W4243562172 hasConceptScore W4243562172C12519072 @default.
• W4243562172 hasConceptScore W4243562172C127561419 @default.
• W4243562172 hasConceptScore W4243562172C153911025 @default.
• W4243562172 hasConceptScore W4243562172C170493617 @default.
• W4243562172 hasConceptScore W4243562172C190283241 @default.
• W4243562172 hasConceptScore W4243562172C2775960820 @default.
• W4243562172 hasConceptScore W4243562172C2777863708 @default.
• W4243562172 hasConceptScore W4243562172C2780362710 @default.
• W4243562172 hasConceptScore W4243562172C28328180 @default.
• W4243562172 hasConceptScore W4243562172C31573885 @default.
• W4243562172 hasConceptScore W4243562172C502942594 @default.
• W4243562172 hasConceptScore W4243562172C54355233 @default.
• W4243562172 hasConceptScore W4243562172C86803240 @default.
• W4243562172 hasConceptScore W4243562172C95444343 @default.
• W4243562172 hasIssue "11" @default.
• W4243562172 hasLocation W42435621721 @default.
• W4243562172 hasOpenAccess W4243562172 @default.

• next