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- W4243568523 abstract "Cell production in all tissues of multicellular organisms is under the control of a network of tissue-specific protein regulators called growth factors. Although the growth factor network may be modulated by circulating hormones, these regulators are usually produced in the tissue in which they function. Growth factors have been identified in the epithelial, neural, lymphoid, myeloid, and hepatic systems; in many cases, a number of closely related growth factors are produced in each tissue. As well as controlling the normal production of mature cells, growth factors are important for regulating inflammatory, wound-healing, and antiviral responses. Many diseases appear to be associated with inappropriate growth factor production or responses. Overproduction of growth factors can lead to accumulation of cellular deposits and infiltration of tissues by inflammatory cells. Although cancers arise as the result of numerous genetic lesions, many metastatic cancers appear to be driven by the autocrine action of growth factors or mutations, which lead to activation of the receptor. New therapeutic approaches to cancer involve the use of specific growth factors to improve hematopoietic recovery from cytotoxic or radiation therapy. Furthermore, growth factor antagonists and growth factor receptor inhibitors are being developed to suppress the proliferation and metastasis of the tumor cells. An understanding of the mechanism of action of growth factors and the range of action of these proteins is also important for developing effective therapies for autoimmune diseases, such as, rheumatoid arthritis, skin diseases, and diabetes." @default.
- W4243568523 created "2022-05-12" @default.
- W4243568523 creator A5053331129 @default.
- W4243568523 date "2006-09-15" @default.
- W4243568523 modified "2023-09-23" @default.
- W4243568523 title "Growth Factors" @default.
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- W4243568523 doi "https://doi.org/10.1002/3527600906.mcb.200300155" @default.
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