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- W4243572235 abstract "There have been several reports of patients with both myasthenia gravis (MG) and inflammatory myositis. Thymic pathology may be contribute to the pathogenesis. We herein describe a patient with distal myositis associated with thymoma, but not accompanied by MG symptom. A 54-year-old man presented with bilateral hands weakness and frequent cramps since 5 weeks ago. Subsequently, generalized myalgia and gait disturbance had developed over several days. Neurological examination revealed symmetric distal dominant weakness in the bilateral upper extremity; however, sensory impairment was not observed. Severe atrophy of the bilateral first dorsal interossei and thenar muscles was noted, and the patient had lost 8 kg over 10 days. The level of serum creatine kinase was elevated at 7431 IU/L and acetylcholine receptor antibody was positive (5.82 nmol/L). Anti-Jo 1 antibody was not detected. The results of nerve conduction study and needle electromyography were compatible with active myopathy. Repetitive nerve stimulation test did not show decremental response on any muscle. Chest computed tomography demonstrated 6.8 cm sized heterogeneously enhancing lobulated mass with internal calcification in the anterior mediastinum. Total thymectomy was done and type B2 thymoma was confirmed. The results of muscle biopsy showed chronic granulomatous and suppurative inflammation with marked neutrophil infiltration which is consistent with thymoma-associated granulomatous myositis. Intravenous methylprednisolone was initiated, and muscle weakness of the patient was much improved. We report a case of thymoma-associated distal myositis which is extremely rare. Thymoma may be associated with diverse neuromuscular disorders including inflammatory myopathy and peripheral neuropathy as well as MG." @default.
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- W4243572235 date "2018-10-01" @default.
- W4243572235 modified "2023-10-18" @default.
- W4243572235 title "INFLAMMATORY MYOPATHIES" @default.
- W4243572235 doi "https://doi.org/10.1016/j.nmd.2018.06.189" @default.
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