Matches in SemOpenAlex for { <https://semopenalex.org/work/W4243582616> ?p ?o ?g. }
Showing items 1 to 61 of
61
with 100 items per page.
- W4243582616 endingPage "380" @default.
- W4243582616 startingPage "377" @default.
- W4243582616 abstract "Chronic obstructive pulmonary disease, irritable bowel syndrome and urinary incontinence are substantial medical conditions that show symptomatic improvement when treated with peripherally acting muscarinic antagonists. The target for these agents is the M3 muscarinic receptor whose over-activity in peripheral autonomic tissues contributes to the unwanted symptoms of cholinergic stimulation. This patent describes a series of N-substituted quinuclidinol esters of acetic acid derivatives that differ from prior antagonists by the introduction of large moieties to the quaternary nitrogen. These agents were shown to exhibit high affinity for the human M3 muscarinic receptor; their affinity for other muscarinic subtypes was not described. It is possible that an antagonist exhibiting selectivity for both M2 and M3 receptors would be preferred because the M2 receptor also contributes to contraction in the smooth muscle of the airways, intestines and urinary bladder." @default.
- W4243582616 created "2022-05-12" @default.
- W4243582616 date "2003-03-01" @default.
- W4243582616 modified "2023-10-14" @default.
- W4243582616 title "N-substituted quinuclidinol esters as potential therapeutic antimuscarinic agents" @default.
- W4243582616 cites W2007829947 @default.
- W4243582616 cites W2095107053 @default.
- W4243582616 cites W2113630547 @default.
- W4243582616 doi "https://doi.org/10.1517/13543776.13.3.377" @default.
- W4243582616 hasPublicationYear "2003" @default.
- W4243582616 type Work @default.
- W4243582616 citedByCount "2" @default.
- W4243582616 crossrefType "journal-article" @default.
- W4243582616 hasConcept C116289061 @default.
- W4243582616 hasConcept C126322002 @default.
- W4243582616 hasConcept C134018914 @default.
- W4243582616 hasConcept C170493617 @default.
- W4243582616 hasConcept C185592680 @default.
- W4243582616 hasConcept C207723603 @default.
- W4243582616 hasConcept C22885893 @default.
- W4243582616 hasConcept C24998067 @default.
- W4243582616 hasConcept C2776723954 @default.
- W4243582616 hasConcept C2776885963 @default.
- W4243582616 hasConcept C33789571 @default.
- W4243582616 hasConcept C47488739 @default.
- W4243582616 hasConcept C71924100 @default.
- W4243582616 hasConcept C98274493 @default.
- W4243582616 hasConceptScore W4243582616C116289061 @default.
- W4243582616 hasConceptScore W4243582616C126322002 @default.
- W4243582616 hasConceptScore W4243582616C134018914 @default.
- W4243582616 hasConceptScore W4243582616C170493617 @default.
- W4243582616 hasConceptScore W4243582616C185592680 @default.
- W4243582616 hasConceptScore W4243582616C207723603 @default.
- W4243582616 hasConceptScore W4243582616C22885893 @default.
- W4243582616 hasConceptScore W4243582616C24998067 @default.
- W4243582616 hasConceptScore W4243582616C2776723954 @default.
- W4243582616 hasConceptScore W4243582616C2776885963 @default.
- W4243582616 hasConceptScore W4243582616C33789571 @default.
- W4243582616 hasConceptScore W4243582616C47488739 @default.
- W4243582616 hasConceptScore W4243582616C71924100 @default.
- W4243582616 hasConceptScore W4243582616C98274493 @default.
- W4243582616 hasIssue "3" @default.
- W4243582616 hasLocation W42435826161 @default.
- W4243582616 hasOpenAccess W4243582616 @default.
- W4243582616 hasPrimaryLocation W42435826161 @default.
- W4243582616 hasRelatedWork W140949363 @default.
- W4243582616 hasRelatedWork W1969093520 @default.
- W4243582616 hasRelatedWork W2035403035 @default.
- W4243582616 hasRelatedWork W2036988181 @default.
- W4243582616 hasRelatedWork W2081320142 @default.
- W4243582616 hasRelatedWork W2094064741 @default.
- W4243582616 hasRelatedWork W2104309281 @default.
- W4243582616 hasRelatedWork W2336699528 @default.
- W4243582616 hasRelatedWork W2409652427 @default.
- W4243582616 hasRelatedWork W758910085 @default.
- W4243582616 hasVolume "13" @default.
- W4243582616 isParatext "false" @default.
- W4243582616 isRetracted "false" @default.
- W4243582616 workType "article" @default.