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- W4243599566 abstract "Insulin is an essential hormone in the higher-order animals, in which it functions to facilitate the assimilation of nutrients and to promote growth (for a review, see ref. 1). The hormone is produced by endocrine cells in the pancreas. In humans, diabetes is often correlated with a relative or absolute deficiency in insulin production, although the precise defect(s) involved has not been determined (2). The primary structure of insulin, first determined by Ryle et al. in 1955 (3), consists of two polypeptide chains (A and B) linked by disulfide bonds. However, the discovery of proinsulin by Steiner and Oyer (4) and, more recently, the identification of preproinsulin (5,6) have clearly established that biosynthesis occurs via these larger precursor forms." @default.
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- W4243599566 date "1987-01-01" @default.
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- W4243599566 title "Insulin Genes" @default.
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- W4243599566 doi "https://doi.org/10.1007/978-1-4612-4824-8_3" @default.
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