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- W4243600510 abstract "The caffeine-evoked effects on the intracellular Ca2+concentration ([Ca2+]i) and on the release of dopamine by PC12 cells were investigated. Stimulation by caffeine resulted in a transient Ca2+release which was followed by a sustained phase of Ca2+entry through a non-voltage dependent pathway. Treatment with cyclopiazonic acid (CPA) or thapsigargin, inhibitors of the Ca2+ATPase pump of the endoplasmic reticulum, resulted in only a sustained rise in [Ca2+]i in the presence of extracellular Ca2+. Pretreatment of cells with CPA or thapsigargin abolished the subsequent Ca2+responses to caffeine. Caffeine also evoked the release of dopamine from the cells only in the presence of extracellular Ca2+, which was mimicked by CPA. These results suggest that store-dependent Ca2+entry evoked by caffeine has an indispensable role in the secretory response in an excitable cell line, PC12 cells." @default.
- W4243600510 created "2022-05-12" @default.
- W4243600510 date "1998-03-01" @default.
- W4243600510 modified "2023-10-14" @default.
- W4243600510 title "Author Index for Volume 244, Number 1" @default.
- W4243600510 doi "https://doi.org/10.1006/bbrc.1998.8260" @default.
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