Matches in SemOpenAlex for { <https://semopenalex.org/work/W4243639332> ?p ?o ?g. }
- W4243639332 endingPage "470" @default.
- W4243639332 startingPage "443" @default.
- W4243639332 abstract "Endothelium-derived hyperpolarizing factor (EDHF) is defined as the non-nitric oxide (NO) and non-prostacyclin (PGI 2 ) substance that mediates endothelium-dependent hyperpolarization (EDH) of vascular smooth muscle cells (VSMC). Although both NO and PGI 2 have been demonstrated to hyperpolarize VSMC by cGMP- and cAMP-dependent mechanisms, respectively, and in the case of NO by cGMP-independent mechanisms, a considerable body of evidence suggests that an additional cellular mechanism must exist that mediates EDH. Despite intensive investigation, there is no agreement as to the nature of the cellular processes that mediates the non-NO/PGI 2 mediated hyperpolarization. Epoxyeicosatrienoic acids (EET), an endogenous anandamide, a small increase in the extracellular concentration of K + , and electronic coupling via myoendothelial cell gap junctions have all been hypothesized as contributors to EDH. An attractive hypothesis is that EDH is mediated via both chemical and electrical transmissions, however, the contribution from chemical mediators versus electrical transmission varies in a tissue- and species-dependent manner, suggesting vessel-specific specialization. If this hypothesis proves to be correct then the potential exists for the development of vessel and organ-selective vasodilators. Because endothelium-dependent vasodilatation is dysfunctional in disease states (i.e., atherosclerosis), selective vasodilators may prove to be important therapeutic agents.Key words: endothelium, nitric oxide, potassium channels, hyperpolarization, gap junctions." @default.
- W4243639332 created "2022-05-12" @default.
- W4243639332 creator A5027044037 @default.
- W4243639332 creator A5062333542 @default.
- W4243639332 creator A5091214681 @default.
- W4243639332 date "2001-06-01" @default.
- W4243639332 modified "2023-09-27" @default.
- W4243639332 title "Endothelium-derived relaxing factors: A focus on endothelium-derived hyperpolarizing factor(s)" @default.
- W4243639332 cites W111614627 @default.
- W4243639332 cites W1488329806 @default.
- W4243639332 cites W1540295714 @default.
- W4243639332 cites W1546802604 @default.
- W4243639332 cites W1550864250 @default.
- W4243639332 cites W1607249944 @default.
- W4243639332 cites W1619653867 @default.
- W4243639332 cites W1753089048 @default.
- W4243639332 cites W178888420 @default.
- W4243639332 cites W1921727696 @default.
- W4243639332 cites W1957610597 @default.
- W4243639332 cites W1964534899 @default.
- W4243639332 cites W1965362276 @default.
- W4243639332 cites W1966358430 @default.
- W4243639332 cites W1967625858 @default.
- W4243639332 cites W1968402657 @default.
- W4243639332 cites W1969453374 @default.
- W4243639332 cites W1970480195 @default.
- W4243639332 cites W1972294775 @default.
- W4243639332 cites W1972701143 @default.
- W4243639332 cites W1972766090 @default.
- W4243639332 cites W1977299564 @default.
- W4243639332 cites W1977608268 @default.
- W4243639332 cites W1979017186 @default.
- W4243639332 cites W1979106984 @default.
- W4243639332 cites W1981936285 @default.
- W4243639332 cites W1982811953 @default.
- W4243639332 cites W1982939007 @default.
- W4243639332 cites W1982993995 @default.
- W4243639332 cites W1983699989 @default.
- W4243639332 cites W1985026297 @default.
- W4243639332 cites W1988126440 @default.
- W4243639332 cites W1988160513 @default.
- W4243639332 cites W1988737490 @default.
- W4243639332 cites W1989744696 @default.
- W4243639332 cites W1991374406 @default.
- W4243639332 cites W1993404169 @default.
- W4243639332 cites W1994452532 @default.
- W4243639332 cites W1994738116 @default.
- W4243639332 cites W1997320622 @default.
- W4243639332 cites W1997557173 @default.
- W4243639332 cites W1997850884 @default.
- W4243639332 cites W1999003094 @default.
- W4243639332 cites W1999551907 @default.
- W4243639332 cites W1999877782 @default.
- W4243639332 cites W2002591410 @default.
- W4243639332 cites W2004092621 @default.
- W4243639332 cites W2004342910 @default.
- W4243639332 cites W2004780745 @default.
- W4243639332 cites W2004883803 @default.
- W4243639332 cites W2005048119 @default.
- W4243639332 cites W2005284425 @default.
- W4243639332 cites W2006405826 @default.
- W4243639332 cites W2007820026 @default.
- W4243639332 cites W2007876689 @default.
- W4243639332 cites W2008197576 @default.
- W4243639332 cites W2009977342 @default.
- W4243639332 cites W2010629576 @default.
- W4243639332 cites W2010958142 @default.
- W4243639332 cites W2011783258 @default.
- W4243639332 cites W2012185701 @default.
- W4243639332 cites W2012833873 @default.
- W4243639332 cites W2012893856 @default.
- W4243639332 cites W2013376946 @default.
- W4243639332 cites W2013939262 @default.
- W4243639332 cites W2015095580 @default.
- W4243639332 cites W2015119500 @default.
- W4243639332 cites W2015305787 @default.
- W4243639332 cites W2016822786 @default.
- W4243639332 cites W2017334143 @default.
- W4243639332 cites W2017716834 @default.
- W4243639332 cites W2020477012 @default.
- W4243639332 cites W2021783313 @default.
- W4243639332 cites W2024663791 @default.
- W4243639332 cites W2026433857 @default.
- W4243639332 cites W2027662236 @default.
- W4243639332 cites W2027813394 @default.
- W4243639332 cites W2028843294 @default.
- W4243639332 cites W2030468978 @default.
- W4243639332 cites W2033323795 @default.
- W4243639332 cites W2035328056 @default.
- W4243639332 cites W2037113953 @default.
- W4243639332 cites W2037550336 @default.
- W4243639332 cites W2038021990 @default.
- W4243639332 cites W2039852315 @default.
- W4243639332 cites W2041049233 @default.
- W4243639332 cites W2041075406 @default.
- W4243639332 cites W2041767355 @default.
- W4243639332 cites W2041854444 @default.
- W4243639332 cites W2041899253 @default.