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- W4243640457 abstract "Eukaryotic messenger ribonucleic acids (mRNAs) possess a tripartite structure that comprises a 5′ untranslated region, a coding region made up of the amino acid coding triplet codons and a 3′ untranslated region. During nuclear maturation of primary transcripts, both ends of mRNA are post-transcriptionally modified through the addition of a 7-methyl-guanosine cap structure at the 5′ end and a polyadenosine tail at the 3′ end. Untranslated regions are involved in the post-transcriptional regulation of gene expression by modulating mRNA stability, nucleo-cytoplasm transport, subcellular localisation and translation efficiency thus allowing a fine control of the protein product. This regulatory activity is mediated by cis-acting oligonucleotide elements that interact with binding proteins and noncoding RNAs through a combination of primary and secondary structures. Key Concepts: UTRs are involved in the post-transcriptional regulation of gene expression. UTRs regulate mRNA stability, nucleo-cytoplasm transport, subcellular localisation and translation efficiency. Alternative splicing can result in mRNAs encoding the same protein under the control of different UTRs." @default.
- W4243640457 created "2022-05-12" @default.
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- W4243640457 date "2011-08-15" @default.
- W4243640457 modified "2023-09-27" @default.
- W4243640457 title "<scp>m</scp> <scp>RNA</scp> Untranslated Regions ( <scp>UTRs</scp> )" @default.
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- W4243640457 doi "https://doi.org/10.1002/9780470015902.a0005009.pub2" @default.
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