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- W4243662342 abstract "Sixteen patients, 13 of whom had received prior chemotherapy, were treated with vindesine for advanced malignant melanoma. Previous treatment included vinca alkaloids in six. Thirteen patients received vindesine, 4 mg/m2 and three received vindesine, 3 mg/m2 by weekly I.V. injection. There were two partial (12%) and no complete responses among all of the patients. Both responses occurred in subcutaneous lesions and lasted for 4 and 6 weeks, respectively. Fifteen patients could be evaluated for treatment-related toxicity. The most common side effect was modest leukopenia (<3000/μl) in 10 patients (67%). The lowest leukocyte count recorded was 1100/μl. Thrombocytopenia was not encountered. Neurotoxicity, manifest most commonly as mild or moderate peripheral paresthesiae, was seen in eight patients (53%)." @default.
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- W4243662342 date "1983-10-01" @default.
- W4243662342 modified "2023-09-25" @default.
- W4243662342 title "Vindesine for metastatic malignant melanoma" @default.
- W4243662342 doi "https://doi.org/10.1097/00000421-198306050-00009" @default.
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