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• W4243670552 abstract "Little attention has been given to the genetic background of APP Tg mice. Each mouse strain has different phenotypes, including hippocampal commissure index, insulin (ng/mL), triglycerides (mg/dL), length of anterior commissure at midsagittal plane (mm). To examine whether genetic background affect on amyloid pathology, APP Tg mice were crossed onto three different strains. APP Tg mice (Tg2576) which are usually maintained by B6/SJL hybrid mice were crossed onto C57BL6/J, SJL/J and DBA2/J inbred strains.The levels of Abeta40 and Abeta42 in Triton and GuHCl fraction from cortex were measured by ELISA. The mRNA level of APP was measured in APP Tg mice and wild type mice. The shortened life span were observed in APP Tg mice with B6 rich genetic background (B6 75%, SJL 25%), which was similar to previous report (Carlson Hum Mol Genet 1997). No significant life span change, however, was observed in the mice with either SJL or DBA rich genetic background. Analysis of 59 APP Tg mice at the age of 12 months showed that lower Abeta accumulation in mice with DBA rich genetic background compared to SJL or B6 rich genetic background. For example,significant difference (p<0.01, Turkey-Kramer) were observed in Abeta40 (-82%)and Abeta42 (-68%) levels in Triton fraction between SJL84% B6 16% mice and DBA75% B6 16% SJL 9%mice. Drastic difference (p<0.01, Turkey-Kramer) were observed in Abeta40 and Abeta42 levels also from GuHCl fraction between SJL 69% B6 31% and DBA 75% B6 16% SJL 9% mice (-85% and -68%) and between SJL 69% B6 31% and DBA 50% B6 31% SJL 19% mice (-75% and -50%). We focus on SJL and DBA, because the difference of Abeta accumulation was most drastic and both genetic backgrounds have no impact on life span. The mRNA level of APP was same in APP Tg mice and wild type mice. Our data demonstrated that genetic background impact on amyloid pathology inAPP Tg mice. These mice can be useful to find the molecular pathways related to amyloid pathology." @default.
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• W4243670552 date "2009-07-01" @default.
• W4243670552 modified "2023-09-27" @default.
• W4243670552 title "P2-132: Drastic impact on Abeta accumulation in APP Tg mice by genetic background" @default.
• W4243670552 doi "https://doi.org/10.1016/j.jalz.2009.04.443" @default.
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