Matches in SemOpenAlex for { <https://semopenalex.org/work/W4243721007> ?p ?o ?g. }
- W4243721007 endingPage "236" @default.
- W4243721007 startingPage "231" @default.
- W4243721007 abstract "Purpose of review Donor shortage in corneal transplantation is a significant problem in Asian countries and is an emerging issue worldwide. This review will discuss current knowledge of the pathogenesis of the rejection mechanism, recent advances in xenocorneal transplantation, and feasibility of porcine xenocorneal graft. Recent findings α-Gal epitopes which are expressed on the porcine cornea, however less than in other vascularized organs. A small animal model provided evidence of complement-mediated or antibody-mediated rejection in porcine xenocorneal transplantation. Recent progress in genetic engineering of the pig or biomedical engineering for removal of the α-Gal epitope appears to have resulted in reduction of antibody-mediated rejection. Porcine corneal xenograft is not rejected hyperacutely in all animal models. T cells predominantly mediate xenocorneal rejection through various animal models. Survival of lamellar fresh porcine grafts is longer than that of full-thickness fresh porcine grafts. Decellularized porcine grafts also demonstrate significantly longer survival than fresh grafts do. Summary Recent studies have documented the potential of the porcine corneal graft as a substitute for use in human allograft and have highlighted the mechanisms of rejection of xenocorneal transplantation. Antibody-mediated or complement-mediated xenogeneic rejection should be further explored in a large animal model." @default.
- W4243721007 created "2022-05-12" @default.
- W4243721007 creator A5011960125 @default.
- W4243721007 creator A5028890231 @default.
- W4243721007 creator A5063319696 @default.
- W4243721007 creator A5071792454 @default.
- W4243721007 date "2011-04-01" @default.
- W4243721007 modified "2023-09-26" @default.
- W4243721007 title "Xenocorneal transplantation" @default.
- W4243721007 cites W1968614352 @default.
- W4243721007 cites W1975327241 @default.
- W4243721007 cites W1977970164 @default.
- W4243721007 cites W1980576607 @default.
- W4243721007 cites W1984911613 @default.
- W4243721007 cites W1988303802 @default.
- W4243721007 cites W1994296419 @default.
- W4243721007 cites W2000052825 @default.
- W4243721007 cites W2000370942 @default.
- W4243721007 cites W2006027213 @default.
- W4243721007 cites W2007494398 @default.
- W4243721007 cites W2008311547 @default.
- W4243721007 cites W2014769247 @default.
- W4243721007 cites W2015198266 @default.
- W4243721007 cites W2020580304 @default.
- W4243721007 cites W2023700481 @default.
- W4243721007 cites W2025697989 @default.
- W4243721007 cites W2031058011 @default.
- W4243721007 cites W2031270356 @default.
- W4243721007 cites W2035417593 @default.
- W4243721007 cites W2045044328 @default.
- W4243721007 cites W2054164188 @default.
- W4243721007 cites W2058360274 @default.
- W4243721007 cites W2061149994 @default.
- W4243721007 cites W2062984113 @default.
- W4243721007 cites W2064057495 @default.
- W4243721007 cites W2074565106 @default.
- W4243721007 cites W2081114413 @default.
- W4243721007 cites W2081240810 @default.
- W4243721007 cites W2095708561 @default.
- W4243721007 cites W2111147092 @default.
- W4243721007 cites W2111432043 @default.
- W4243721007 cites W2122300492 @default.
- W4243721007 cites W2124129307 @default.
- W4243721007 cites W2132563354 @default.
- W4243721007 cites W2137358128 @default.
- W4243721007 cites W2137634455 @default.
- W4243721007 cites W2146038093 @default.
- W4243721007 cites W2146092834 @default.
- W4243721007 cites W2160603504 @default.
- W4243721007 cites W2163649189 @default.
- W4243721007 cites W2165365345 @default.
- W4243721007 cites W2166399371 @default.
- W4243721007 doi "https://doi.org/10.1097/mot.0b013e328344870c" @default.
- W4243721007 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21415826" @default.
- W4243721007 hasPublicationYear "2011" @default.
- W4243721007 type Work @default.
- W4243721007 citedByCount "36" @default.
- W4243721007 countsByYear W42437210072012 @default.
- W4243721007 countsByYear W42437210072013 @default.
- W4243721007 countsByYear W42437210072014 @default.
- W4243721007 countsByYear W42437210072015 @default.
- W4243721007 countsByYear W42437210072016 @default.
- W4243721007 countsByYear W42437210072017 @default.
- W4243721007 countsByYear W42437210072018 @default.
- W4243721007 countsByYear W42437210072019 @default.
- W4243721007 countsByYear W42437210072020 @default.
- W4243721007 crossrefType "journal-article" @default.
- W4243721007 hasAuthorship W4243721007A5011960125 @default.
- W4243721007 hasAuthorship W4243721007A5028890231 @default.
- W4243721007 hasAuthorship W4243721007A5063319696 @default.
- W4243721007 hasAuthorship W4243721007A5071792454 @default.
- W4243721007 hasConcept C118487528 @default.
- W4243721007 hasConcept C126322002 @default.
- W4243721007 hasConcept C136229726 @default.
- W4243721007 hasConcept C138885662 @default.
- W4243721007 hasConcept C141071460 @default.
- W4243721007 hasConcept C159654299 @default.
- W4243721007 hasConcept C190672674 @default.
- W4243721007 hasConcept C194051981 @default.
- W4243721007 hasConcept C195616568 @default.
- W4243721007 hasConcept C203014093 @default.
- W4243721007 hasConcept C2776882836 @default.
- W4243721007 hasConcept C2778117688 @default.
- W4243721007 hasConcept C2778137410 @default.
- W4243721007 hasConcept C2778442404 @default.
- W4243721007 hasConcept C2780686511 @default.
- W4243721007 hasConcept C2911091166 @default.
- W4243721007 hasConcept C41895202 @default.
- W4243721007 hasConcept C49892992 @default.
- W4243721007 hasConcept C71924100 @default.
- W4243721007 hasConcept C86803240 @default.
- W4243721007 hasConceptScore W4243721007C118487528 @default.
- W4243721007 hasConceptScore W4243721007C126322002 @default.
- W4243721007 hasConceptScore W4243721007C136229726 @default.
- W4243721007 hasConceptScore W4243721007C138885662 @default.
- W4243721007 hasConceptScore W4243721007C141071460 @default.
- W4243721007 hasConceptScore W4243721007C159654299 @default.
- W4243721007 hasConceptScore W4243721007C190672674 @default.