Matches in SemOpenAlex for { <https://semopenalex.org/work/W4243722963> ?p ?o ?g. }
Showing items 1 to 67 of
67
with 100 items per page.
- W4243722963 endingPage "671" @default.
- W4243722963 startingPage "667" @default.
- W4243722963 abstract "Abnormalities of T lymphocytes in B cell chronic lymphocytic leukemia (B-CLL) have been extensively documented by several immunologic investigations. Following recent studies pointing to the favorable effect of TP-1, a partially purified extract of calf thymus, on the T cell-mediated immunity of several diseases, including Hodgkin's disease, we have used monoclonal antibodies and the enriched T lymphocytes of 16 untreated B-CLL patients to evaluate the proportion of T cell subsets before and after the administration of TP-1. In addition, the proliferative response to phytohemagglutinin (PHA) and the helper function in a pokeweed mitogen (PWM) system were assessed. In ten cases, the effect of TP-1 was also studied in vitro by evaluating the same parameters before and after incubation of B-CLL T cells with the drug. The study demonstrated that in vivo administration of TP-1 increases significantly (P less than .001) the proportion of the defective helper/inducer T cell population (OKT4-positive cells) in B-CLL, leading to a near normal OKT4/OKT8 ratio. Furthermore, the improved phenotypic profile was accompanied by an increased proliferative response to PHA and, in particular, by a significant increase (P less than .01) of T helper capacity; this increase was, however, insufficient to enable the normalization of the serum immunoglobulin levels. The in vitro incubation of B-CLL T lymphocytes did not succeed in producing significant modifications in distribution and function." @default.
- W4243722963 created "2022-05-12" @default.
- W4243722963 creator A5038478275 @default.
- W4243722963 creator A5040669844 @default.
- W4243722963 creator A5082496212 @default.
- W4243722963 date "1984-09-01" @default.
- W4243722963 modified "2023-10-01" @default.
- W4243722963 title "Effect of a thymic factor on T lymphocytes in B cell chronic lymphocytic leukemia: in vitro and in vivo studies" @default.
- W4243722963 doi "https://doi.org/10.1182/blood.v64.3.667.bloodjournal643667" @default.
- W4243722963 hasPublicationYear "1984" @default.
- W4243722963 type Work @default.
- W4243722963 citedByCount "0" @default.
- W4243722963 crossrefType "journal-article" @default.
- W4243722963 hasAuthorship W4243722963A5038478275 @default.
- W4243722963 hasAuthorship W4243722963A5040669844 @default.
- W4243722963 hasAuthorship W4243722963A5082496212 @default.
- W4243722963 hasBestOaLocation W42437229631 @default.
- W4243722963 hasConcept C150903083 @default.
- W4243722963 hasConcept C159654299 @default.
- W4243722963 hasConcept C202751555 @default.
- W4243722963 hasConcept C203014093 @default.
- W4243722963 hasConcept C207001950 @default.
- W4243722963 hasConcept C2776090121 @default.
- W4243722963 hasConcept C2777938653 @default.
- W4243722963 hasConcept C2778453870 @default.
- W4243722963 hasConcept C2778461978 @default.
- W4243722963 hasConcept C2908647359 @default.
- W4243722963 hasConcept C55493867 @default.
- W4243722963 hasConcept C71924100 @default.
- W4243722963 hasConcept C86803240 @default.
- W4243722963 hasConcept C8891405 @default.
- W4243722963 hasConcept C99454951 @default.
- W4243722963 hasConceptScore W4243722963C150903083 @default.
- W4243722963 hasConceptScore W4243722963C159654299 @default.
- W4243722963 hasConceptScore W4243722963C202751555 @default.
- W4243722963 hasConceptScore W4243722963C203014093 @default.
- W4243722963 hasConceptScore W4243722963C207001950 @default.
- W4243722963 hasConceptScore W4243722963C2776090121 @default.
- W4243722963 hasConceptScore W4243722963C2777938653 @default.
- W4243722963 hasConceptScore W4243722963C2778453870 @default.
- W4243722963 hasConceptScore W4243722963C2778461978 @default.
- W4243722963 hasConceptScore W4243722963C2908647359 @default.
- W4243722963 hasConceptScore W4243722963C55493867 @default.
- W4243722963 hasConceptScore W4243722963C71924100 @default.
- W4243722963 hasConceptScore W4243722963C86803240 @default.
- W4243722963 hasConceptScore W4243722963C8891405 @default.
- W4243722963 hasConceptScore W4243722963C99454951 @default.
- W4243722963 hasIssue "3" @default.
- W4243722963 hasLocation W42437229631 @default.
- W4243722963 hasOpenAccess W4243722963 @default.
- W4243722963 hasPrimaryLocation W42437229631 @default.
- W4243722963 hasRelatedWork W16628677 @default.
- W4243722963 hasRelatedWork W19278329 @default.
- W4243722963 hasRelatedWork W20841648 @default.
- W4243722963 hasRelatedWork W2269536 @default.
- W4243722963 hasRelatedWork W3807280 @default.
- W4243722963 hasRelatedWork W385850 @default.
- W4243722963 hasRelatedWork W4281585 @default.
- W4243722963 hasRelatedWork W4467917 @default.
- W4243722963 hasRelatedWork W4732904 @default.
- W4243722963 hasRelatedWork W5130503 @default.
- W4243722963 hasVolume "64" @default.
- W4243722963 isParatext "false" @default.
- W4243722963 isRetracted "false" @default.
- W4243722963 workType "article" @default.