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• W4243724299 abstract "Primary CNS lymphoma (PCNSL) is a rapidly fatal and highly malignant multifocal disease of the CNS. Once thought to be relatively rare, PCNSL now affects approximately two per million population and the incidence has tripled during the last decade (1,2). This increase in the frequency of PCNSL accounts for the fact that it is now responsible for approx 3% of all intracranial tumors. Although this disease has been shown to occur at an increased frequency among patients with immunodeficiency disorders, such as collagen vascular disease or AIDS, the majority of patients are still those who do not have any underlying immunological disorder (3,4). Eby and colleagues have postulated that one reason for this increase may be because of environmental factors or a possible viral entity (5). Indeed, PCNSL frequently occurs in association with Epstein-Barr virus (EBV) infection, especially among patients who are immunocompromised (6,7). Overall, about 6% of patients with AIDS develop PCNSL. In fact, among patients with AIDS, PCNSL occurs as frequently and perhaps even more frequently than toxoplasmosis, once the most common mass lesion of the CNS occurring in AIDS patients (3).KeywordsHuman Immunodeficiency VirusGene TherapyAcquire Immune Deficiency SyndromePrimary Central Nervous System LymphomaCentral Nervous System LymphomaThese keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves." @default.
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• W4243724299 date "1998-01-01" @default.
• W4243724299 modified "2023-09-23" @default.
• W4243724299 title "EBV Vectors" @default.
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• W4243724299 doi "https://doi.org/10.1007/978-1-59259-478-8_6" @default.
• W4243724299 hasPublicationYear "1998" @default.
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