Matches in SemOpenAlex for { <https://semopenalex.org/work/W4243735504> ?p ?o ?g. }
Showing items 1 to 81 of
81
with 100 items per page.
- W4243735504 endingPage "4669" @default.
- W4243735504 startingPage "4666" @default.
- W4243735504 abstract "Abstract Herein, we present the peptide‐guided assembly of complementary fragments of designed armadillo repeat proteins (dArmRPs) to create proteins that bind peptides not only with high affinity but also with good selectivity. We recently demonstrated that complementary N‐ and C‐terminal fragments of dArmRPs form high‐affinity complexes that resemble the structure of the full‐length protein, and that these complexes bind their target peptides. We now demonstrate that dArmRPs can be split such that the fragments assemble only in the presence of a templating peptide, and that fragment mixtures enrich the combination with the highest affinity for this peptide. The enriched fragment combination discriminates single amino acid variations in the target peptide with high specificity. Our results suggest novel opportunities for the generation of new peptide binders by selection from dArmRP fragment mixtures." @default.
- W4243735504 created "2022-05-12" @default.
- W4243735504 creator A5049373174 @default.
- W4243735504 creator A5058635369 @default.
- W4243735504 creator A5083658123 @default.
- W4243735504 date "2018-03-13" @default.
- W4243735504 modified "2023-09-24" @default.
- W4243735504 title "Peptide‐Guided Assembly of Repeat Protein Fragments" @default.
- W4243735504 cites W1581422226 @default.
- W4243735504 cites W1954202239 @default.
- W4243735504 cites W1972866754 @default.
- W4243735504 cites W1990557050 @default.
- W4243735504 cites W2011261569 @default.
- W4243735504 cites W2028320405 @default.
- W4243735504 cites W2030497790 @default.
- W4243735504 cites W2039452868 @default.
- W4243735504 cites W2047199560 @default.
- W4243735504 cites W2067337497 @default.
- W4243735504 cites W2107532817 @default.
- W4243735504 cites W2109366214 @default.
- W4243735504 cites W2148521301 @default.
- W4243735504 cites W2154833904 @default.
- W4243735504 cites W2156757529 @default.
- W4243735504 cites W2156891333 @default.
- W4243735504 cites W2165238581 @default.
- W4243735504 cites W2283061916 @default.
- W4243735504 cites W2517316787 @default.
- W4243735504 cites W2523172184 @default.
- W4243735504 doi "https://doi.org/10.1002/ange.201713377" @default.
- W4243735504 hasPublicationYear "2018" @default.
- W4243735504 type Work @default.
- W4243735504 citedByCount "1" @default.
- W4243735504 countsByYear W42437355042020 @default.
- W4243735504 crossrefType "journal-article" @default.
- W4243735504 hasAuthorship W4243735504A5049373174 @default.
- W4243735504 hasAuthorship W4243735504A5058635369 @default.
- W4243735504 hasAuthorship W4243735504A5083658123 @default.
- W4243735504 hasBestOaLocation W42437355042 @default.
- W4243735504 hasConcept C104317684 @default.
- W4243735504 hasConcept C167625842 @default.
- W4243735504 hasConcept C185592680 @default.
- W4243735504 hasConcept C199360897 @default.
- W4243735504 hasConcept C21951064 @default.
- W4243735504 hasConcept C2776235265 @default.
- W4243735504 hasConcept C2779281246 @default.
- W4243735504 hasConcept C3017395165 @default.
- W4243735504 hasConcept C41008148 @default.
- W4243735504 hasConcept C55493867 @default.
- W4243735504 hasConceptScore W4243735504C104317684 @default.
- W4243735504 hasConceptScore W4243735504C167625842 @default.
- W4243735504 hasConceptScore W4243735504C185592680 @default.
- W4243735504 hasConceptScore W4243735504C199360897 @default.
- W4243735504 hasConceptScore W4243735504C21951064 @default.
- W4243735504 hasConceptScore W4243735504C2776235265 @default.
- W4243735504 hasConceptScore W4243735504C2779281246 @default.
- W4243735504 hasConceptScore W4243735504C3017395165 @default.
- W4243735504 hasConceptScore W4243735504C41008148 @default.
- W4243735504 hasConceptScore W4243735504C55493867 @default.
- W4243735504 hasFunder F4320320924 @default.
- W4243735504 hasFunder F4320323874 @default.
- W4243735504 hasIssue "17" @default.
- W4243735504 hasLocation W42437355041 @default.
- W4243735504 hasLocation W42437355042 @default.
- W4243735504 hasOpenAccess W4243735504 @default.
- W4243735504 hasPrimaryLocation W42437355041 @default.
- W4243735504 hasRelatedWork W1542525184 @default.
- W4243735504 hasRelatedWork W2026459752 @default.
- W4243735504 hasRelatedWork W2073199546 @default.
- W4243735504 hasRelatedWork W2148218291 @default.
- W4243735504 hasRelatedWork W2170183443 @default.
- W4243735504 hasRelatedWork W2573801419 @default.
- W4243735504 hasRelatedWork W2950983720 @default.
- W4243735504 hasRelatedWork W3203307615 @default.
- W4243735504 hasRelatedWork W4244667361 @default.
- W4243735504 hasRelatedWork W4385362992 @default.
- W4243735504 hasVolume "130" @default.
- W4243735504 isParatext "false" @default.
- W4243735504 isRetracted "false" @default.
- W4243735504 workType "article" @default.