FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4243759432> ?p ?o ?g. }

• W4243759432 endingPage "991" @default.
• W4243759432 startingPage "991" @default.
• W4243759432 abstract "Correspondence1 October 2011free access Of mice and men Thomas C Erren Thomas C Erren Institute and Policlinic for Occupational Medicine, Environmental Medicine and Prevention Research at the University of Cologne, Germany Search for more papers by this author J Valérie Groß J Valérie Groß Institute and Policlinic for Occupational Medicine, Environmental Medicine and Prevention Research Search for more papers by this author Melissa S Koch Melissa S Koch Institute and Policlinic for Occupational Medicine, Environmental Medicine and Prevention Research Search for more papers by this author V Benno Meyer-Rochow V Benno Meyer-Rochow School of Engineering and Science, Jacobs University Bremen, Germany Departments of Biology and Physiology of the University of Oulu, Finland Search for more papers by this author Thomas C Erren Thomas C Erren Institute and Policlinic for Occupational Medicine, Environmental Medicine and Prevention Research at the University of Cologne, Germany Search for more papers by this author J Valérie Groß J Valérie Groß Institute and Policlinic for Occupational Medicine, Environmental Medicine and Prevention Research Search for more papers by this author Melissa S Koch Melissa S Koch Institute and Policlinic for Occupational Medicine, Environmental Medicine and Prevention Research Search for more papers by this author V Benno Meyer-Rochow V Benno Meyer-Rochow School of Engineering and Science, Jacobs University Bremen, Germany Departments of Biology and Physiology of the University of Oulu, Finland Search for more papers by this author Author Information Thomas C Erren1, J Valérie Groß2, Melissa S Koch2 and V Benno Meyer-Rochow3,4 1Institute and Policlinic for Occupational Medicine, Environmental Medicine and Prevention Research at the University of Cologne, Germany 2Institute and Policlinic for Occupational Medicine, Environmental Medicine and Prevention Research 3School of Engineering and Science, Jacobs University Bremen, Germany 4Departments of Biology and Physiology of the University of Oulu, Finland EMBO Reports (2011)12:991-991https://doi.org/10.1038/embor.2011.185 PDFDownload PDF of article text and main figures. ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinked InMendeleyWechatReddit Figures & Info We would like to compliment, and complement, the recent Opinion in EMBO reports by Stuart Peirson and Russell Foster (2011), which calls attention to the potential obstacles associated with linking observations on light and circadian rhythmicity made on nocturnal mice to diurnally active humans. Pitfalls to consider include that qualitative extrapolations from short-lived rodents to long-lived humans, quantitative extrapolations of very different doses (Gold et al, 1992), and the varying sensitivities of each species to experimental optical radiation as a circadian stimulus (Bullough et al, 2006) can all have a critical influence on an experiment. Thus, Peirson & Foster remind us that “humans are not big mice”. We certainly agree, but we also thought it worthwhile to point out that human studies have their own interesting pitfalls, of which all researchers should be mindful. Many investigations with humans—such as testing the effects of different light exposures on alertness, cognitive performance, well-being and depression—can suffer from what has been coined as the ‘Hawthorne effect’. The term is derived from a series of studies conducted at the Western Electric Company's Hawthorne Works near Chicago, Illinois, between 1924 and 1932, to test whether the productivity of workers would change with changing illumination levels. One important punch line was that productivity increased with almost any change that was made at the workplaces. One prevailing interpretation of these findings is that humans who know that they are being studied—and in most investigations they cannot help but notice—might exhibit responses that have little or nothing to do with what was intended as the experiment. Those who conduct circadian biology studies in humans try hard to eliminate possible ‘Hawthorne effects’, but every so often, all they can do is to hope for the best and expect the Hawthorne effect to be insignificant. Even so, and despite the obstacles to circadian experiments with both mice and humans, the wealth of information from work in both species is indispensable. To exemplify, in the last handful of years alone, experimental research in mice has substantially contributed to our understanding of the retinal interface between visible light and circadian circuitry (Chen et al, 2011); has shown that disturbances of the circadian systems through manipulations of the light–dark cycles might accelerate carcinogenesis (Filipski et al, 2009); and has suggested that perinatal light exposure—through an imprinting of the stability of circadian systems (Ciarleglio et al, 2011)—might be related to a human's susceptibility to mood disorders (Erren et al, 2011a) and internal cancer developments later in life (Erren et al, 2011b). Future studies in humans must now examine whether, and to what extent, what was found in mice is applicable to and relevant for humans. The bottom line is that we must be aware of, and first and foremost exploit, evolutionary legacies, such as the seemingly ubiquitous photoreceptive clockwork that marine and terrestrial vertebrates—including mammals such as mice and humans—share (Erren et al, 2008). Translating insights from studies in animals to humans (Erren et al, 2011a,b), and vice versa, into testable research can be a means to one end: to arrive at sensible answers to pressing questions about light and circadian clockworks that, no doubt, play key roles in human health and disease. Pitfalls, however, abound on either side, and we agree with Peirson & Foster that they have to be recognized and monitored. Conflict of Interest The authors declare that they have no conflict of interest. Biographies Thomas C Erren is Professor of Occupational and Environmental Medicine and Director of the Institute and Policlinic for Occupational Medicine, Environmental Medicine and Prevention Research at the University of Cologne, Germany. E-mail: [email protected] J Valérie Groß and Melissa S Koch are research scientists also at the Institute and Policlinic for Occupational Medicine, Environmental Medicine and Prevention Research. V Benno Meyer-Rochow is Professor of Biology at the School of Engineering and Science, Jacobs University Bremen, Germany, and docent in the Departments of Biology and Physiology of the University of Oulu, Finland. References Bullough JD, Rea MS, Figueiro MG (2006) Cancer Causes Control 17: 375–383CrossrefPubMedWeb of Science®Google Scholar Chen SK, Badea TC, Hattar S (2011) Nature 476: 92–95CrossrefCASPubMedWeb of Science®Google Scholar Ciarleglio CM, Axley JC, Strauss BR, Gamble KL, McMahon DGA (2011) Nat Neurosci 14: 25–27CrossrefCASPubMedWeb of Science®Google Scholar Erren TC, Nise MS, Meyer-Rochow VB (2011a) Psychopharmacology 216: 147–148CrossrefCASWeb of Science®Google Scholar Erren TC, Groβ JV, Meyer-Rochow VB (2011b) Chronobiol Int 28: 471–473CrossrefPubMedWeb of Science®Google Scholar Erren TC, Erren M, Lerchi A, Meyer-Rochow VB (2008) Naturwissenschaften 95: 273–279CrossrefCASPubMedWeb of Science®Google Scholar Filipski E, Subramanian P, Carrière J, Guettier C, Barbason H, Lévi F (2009) Mutat Res 680: 95–105CrossrefCASPubMedWeb of Science®Google Scholar Gold LS, Manley NB, Ames BN (1992) Risk Anal 12: 579–588Wiley Online LibraryCASPubMedWeb of Science®Google Scholar Peirson SN, Foster RG (2011) EMBO Rep 12: 380Wiley Online LibraryCASWeb of Science®Google Scholar Previous ArticleNext Article Volume 12Issue 101 October 2011In this issue ReferencesRelatedDetailsLoading ..." @default.
• W4243759432 created "2022-05-12" @default.
• W4243759432 creator A5004206716 @default.
• W4243759432 creator A5028138187 @default.
• W4243759432 creator A5087790644 @default.
• W4243759432 creator A5087873580 @default.
• W4243759432 date "2011-10-01" @default.
• W4243759432 modified "2023-10-14" @default.
• W4243759432 title "Of mice and men" @default.
• W4243759432 cites W1995945554 @default.
• W4243759432 cites W2003519988 @default.
• W4243759432 cites W2047816219 @default.
• W4243759432 cites W2051225669 @default.
• W4243759432 cites W2053243600 @default.
• W4243759432 cites W2055874289 @default.
• W4243759432 cites W2061683639 @default.
• W4243759432 cites W2079493891 @default.
• W4243759432 cites W2104300586 @default.
• W4243759432 doi "https://doi.org/10.1038/embor.2011.185" @default.
• W4243759432 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21921937" @default.
• W4243759432 hasPublicationYear "2011" @default.
• W4243759432 type Work @default.
• W4243759432 citedByCount "3" @default.
• W4243759432 countsByYear W42437594322012 @default.
• W4243759432 countsByYear W42437594322017 @default.
• W4243759432 countsByYear W42437594322018 @default.
• W4243759432 crossrefType "journal-article" @default.
• W4243759432 hasAuthorship W4243759432A5004206716 @default.
• W4243759432 hasAuthorship W4243759432A5028138187 @default.
• W4243759432 hasAuthorship W4243759432A5087790644 @default.
• W4243759432 hasAuthorship W4243759432A5087873580 @default.
• W4243759432 hasBestOaLocation W42437594322 @default.
• W4243759432 hasConcept C86803240 @default.
• W4243759432 hasConceptScore W4243759432C86803240 @default.
• W4243759432 hasIssue "10" @default.
• W4243759432 hasLocation W42437594321 @default.
• W4243759432 hasLocation W42437594322 @default.
• W4243759432 hasLocation W42437594323 @default.
• W4243759432 hasLocation W42437594324 @default.
• W4243759432 hasOpenAccess W4243759432 @default.
• W4243759432 hasPrimaryLocation W42437594321 @default.
• W4243759432 hasRelatedWork W1641042124 @default.
• W4243759432 hasRelatedWork W1990804418 @default.
• W4243759432 hasRelatedWork W1993764875 @default.
• W4243759432 hasRelatedWork W2013243191 @default.
• W4243759432 hasRelatedWork W2046158694 @default.
• W4243759432 hasRelatedWork W2082860237 @default.
• W4243759432 hasRelatedWork W2117258802 @default.
• W4243759432 hasRelatedWork W2130076355 @default.
• W4243759432 hasRelatedWork W2151865869 @default.
• W4243759432 hasRelatedWork W4234157524 @default.
• W4243759432 hasVolume "12" @default.
• W4243759432 isParatext "false" @default.
• W4243759432 isRetracted "false" @default.
• W4243759432 workType "article" @default.