Matches in SemOpenAlex for { <https://semopenalex.org/work/W4243766672> ?p ?o ?g. }
Showing items 1 to 66 of
66
with 100 items per page.
- W4243766672 abstract "Protein production through dedicated secretion systems might offer an potential alternative to the conventional cytoplasmical expression. The application of Type 1 secretion systems of Gram-negative bacteria, however, where often not successful in the past for a wide range of proteins. Recently, two studies using the E. coli maltose binding protein (MalE) and the rat intestinal fatty acid binding protein (IFABP) revealed a rational to circumvent these limitations. Here, wild-type passenger proteins were not secreted, while folding mutants with decreased folding kinetics were efficiently exported to the extracellular space. Subsequently, an one-step purification protocol yielded homogeneous and active protein. Taken together, theses two studies suggest that the introduction of slow-folding mutations into a protein sequence might be the key to use Type 1 secretion systems for the biotechnological production of proteins." @default.
- W4243766672 created "2022-05-12" @default.
- W4243766672 creator A5000083210 @default.
- W4243766672 creator A5027680919 @default.
- W4243766672 creator A5047392065 @default.
- W4243766672 creator A5077256764 @default.
- W4243766672 date "2012-09-01" @default.
- W4243766672 modified "2023-09-25" @default.
- W4243766672 title "Secretion of slow-folding proteins by a Type 1 Secretion System." @default.
- W4243766672 doi "https://doi.org/10.4161/bbug.20712" @default.
- W4243766672 hasPublicationYear "2012" @default.
- W4243766672 type Work @default.
- W4243766672 citedByCount "0" @default.
- W4243766672 crossrefType "journal-article" @default.
- W4243766672 hasAuthorship W4243766672A5000083210 @default.
- W4243766672 hasAuthorship W4243766672A5027680919 @default.
- W4243766672 hasAuthorship W4243766672A5047392065 @default.
- W4243766672 hasAuthorship W4243766672A5077256764 @default.
- W4243766672 hasBestOaLocation W42437666721 @default.
- W4243766672 hasConcept C104317684 @default.
- W4243766672 hasConcept C119599485 @default.
- W4243766672 hasConcept C123894998 @default.
- W4243766672 hasConcept C127413603 @default.
- W4243766672 hasConcept C143065580 @default.
- W4243766672 hasConcept C156399914 @default.
- W4243766672 hasConcept C204328495 @default.
- W4243766672 hasConcept C2776545253 @default.
- W4243766672 hasConcept C2780676925 @default.
- W4243766672 hasConcept C40767141 @default.
- W4243766672 hasConcept C49039625 @default.
- W4243766672 hasConcept C55493867 @default.
- W4243766672 hasConcept C86803240 @default.
- W4243766672 hasConcept C95444343 @default.
- W4243766672 hasConceptScore W4243766672C104317684 @default.
- W4243766672 hasConceptScore W4243766672C119599485 @default.
- W4243766672 hasConceptScore W4243766672C123894998 @default.
- W4243766672 hasConceptScore W4243766672C127413603 @default.
- W4243766672 hasConceptScore W4243766672C143065580 @default.
- W4243766672 hasConceptScore W4243766672C156399914 @default.
- W4243766672 hasConceptScore W4243766672C204328495 @default.
- W4243766672 hasConceptScore W4243766672C2776545253 @default.
- W4243766672 hasConceptScore W4243766672C2780676925 @default.
- W4243766672 hasConceptScore W4243766672C40767141 @default.
- W4243766672 hasConceptScore W4243766672C49039625 @default.
- W4243766672 hasConceptScore W4243766672C55493867 @default.
- W4243766672 hasConceptScore W4243766672C86803240 @default.
- W4243766672 hasConceptScore W4243766672C95444343 @default.
- W4243766672 hasIssue "5" @default.
- W4243766672 hasLocation W42437666721 @default.
- W4243766672 hasLocation W42437666722 @default.
- W4243766672 hasOpenAccess W4243766672 @default.
- W4243766672 hasPrimaryLocation W42437666721 @default.
- W4243766672 hasRelatedWork W2010411596 @default.
- W4243766672 hasRelatedWork W2010527332 @default.
- W4243766672 hasRelatedWork W2054357181 @default.
- W4243766672 hasRelatedWork W2139994008 @default.
- W4243766672 hasRelatedWork W2330038357 @default.
- W4243766672 hasRelatedWork W2423726595 @default.
- W4243766672 hasRelatedWork W3086093045 @default.
- W4243766672 hasRelatedWork W3133088740 @default.
- W4243766672 hasRelatedWork W3191834672 @default.
- W4243766672 hasRelatedWork W4210252054 @default.
- W4243766672 hasVolume "3" @default.
- W4243766672 isParatext "false" @default.
- W4243766672 isRetracted "false" @default.
- W4243766672 workType "article" @default.