Matches in SemOpenAlex for { <https://semopenalex.org/work/W4243774516> ?p ?o ?g. }
Showing items 1 to 89 of
89
with 100 items per page.
- W4243774516 abstract "Abstract Background: Alzheimer’s disease (AD), which is among the most prevalent neurodegenerative diseases, manifests as increasing memory loss and cognitive decline. Tau phosphorylation and aggregation are strongly linked to neurodegeneration as well as associated with chronic neuroinflammatory processes. The anti-inflammation effects of natural products have led to wide recognition of their potential for use in treating and preventing AD. This study investigated whether eupatin, a polymethoxyflavonoid found in Artemisia species, has inhibitory effects on neuroinflammation and tau phosphorylation. Methods: We treated mouse macrophages and microglia cells with lipopolysaccharides (LPSs) to activate inflammatory signals, and we treated neuronal cells with a protein phosphatase 2A inhibitor, okadaic acid (OA), or transfection with pRK5-EGFP-Tau P301L plasmid to induce tau phosphorylation. Results: The results indicated that eupatin significantly reduced the LPS-induced protein expression and phosphorylation of p65 and inducible nitric oxide synthase as well as downstream products interleukin 6 and nitrite, respectively. Furthermore, eupatin markedly inhibited the expression of phospho-tau in response to OA treatment and plasmid transfection. We discovered that this inhibition was achieved through the inhibition of glycogen synthase kinase 3β (GSK3b), and molecular docking results suggested that eupatin can sufficiently bind to the GSK3b active site. Conclusion: Our results demonstrate that eupatin has neuroprotective effects, making it suitable for AD treatment." @default.
- W4243774516 created "2022-05-12" @default.
- W4243774516 creator A5001793326 @default.
- W4243774516 creator A5057038322 @default.
- W4243774516 creator A5057602145 @default.
- W4243774516 creator A5062729939 @default.
- W4243774516 date "2020-11-17" @default.
- W4243774516 modified "2023-10-18" @default.
- W4243774516 title "Anti-Inflammatory and Tau Phosphorylation–Inhibitory Effects of Eupatin" @default.
- W4243774516 doi "https://doi.org/10.21203/rs.3.rs-104140/v1" @default.
- W4243774516 hasPublicationYear "2020" @default.
- W4243774516 type Work @default.
- W4243774516 citedByCount "2" @default.
- W4243774516 countsByYear W42437745162023 @default.
- W4243774516 crossrefType "posted-content" @default.
- W4243774516 hasAuthorship W4243774516A5001793326 @default.
- W4243774516 hasAuthorship W4243774516A5057038322 @default.
- W4243774516 hasAuthorship W4243774516A5057602145 @default.
- W4243774516 hasAuthorship W4243774516A5062729939 @default.
- W4243774516 hasBestOaLocation W42437745161 @default.
- W4243774516 hasConcept C104317684 @default.
- W4243774516 hasConcept C104629339 @default.
- W4243774516 hasConcept C11960822 @default.
- W4243774516 hasConcept C126322002 @default.
- W4243774516 hasConcept C178666793 @default.
- W4243774516 hasConcept C181199279 @default.
- W4243774516 hasConcept C182996813 @default.
- W4243774516 hasConcept C185592680 @default.
- W4243774516 hasConcept C192118531 @default.
- W4243774516 hasConcept C203014093 @default.
- W4243774516 hasConcept C25498285 @default.
- W4243774516 hasConcept C2776914184 @default.
- W4243774516 hasConcept C2776925932 @default.
- W4243774516 hasConcept C2776953658 @default.
- W4243774516 hasConcept C2777622882 @default.
- W4243774516 hasConcept C2778670691 @default.
- W4243774516 hasConcept C2779134260 @default.
- W4243774516 hasConcept C2779830541 @default.
- W4243774516 hasConcept C502032728 @default.
- W4243774516 hasConcept C54009773 @default.
- W4243774516 hasConcept C55493867 @default.
- W4243774516 hasConcept C71924100 @default.
- W4243774516 hasConcept C86803240 @default.
- W4243774516 hasConcept C87753298 @default.
- W4243774516 hasConcept C95444343 @default.
- W4243774516 hasConcept C98274493 @default.
- W4243774516 hasConceptScore W4243774516C104317684 @default.
- W4243774516 hasConceptScore W4243774516C104629339 @default.
- W4243774516 hasConceptScore W4243774516C11960822 @default.
- W4243774516 hasConceptScore W4243774516C126322002 @default.
- W4243774516 hasConceptScore W4243774516C178666793 @default.
- W4243774516 hasConceptScore W4243774516C181199279 @default.
- W4243774516 hasConceptScore W4243774516C182996813 @default.
- W4243774516 hasConceptScore W4243774516C185592680 @default.
- W4243774516 hasConceptScore W4243774516C192118531 @default.
- W4243774516 hasConceptScore W4243774516C203014093 @default.
- W4243774516 hasConceptScore W4243774516C25498285 @default.
- W4243774516 hasConceptScore W4243774516C2776914184 @default.
- W4243774516 hasConceptScore W4243774516C2776925932 @default.
- W4243774516 hasConceptScore W4243774516C2776953658 @default.
- W4243774516 hasConceptScore W4243774516C2777622882 @default.
- W4243774516 hasConceptScore W4243774516C2778670691 @default.
- W4243774516 hasConceptScore W4243774516C2779134260 @default.
- W4243774516 hasConceptScore W4243774516C2779830541 @default.
- W4243774516 hasConceptScore W4243774516C502032728 @default.
- W4243774516 hasConceptScore W4243774516C54009773 @default.
- W4243774516 hasConceptScore W4243774516C55493867 @default.
- W4243774516 hasConceptScore W4243774516C71924100 @default.
- W4243774516 hasConceptScore W4243774516C86803240 @default.
- W4243774516 hasConceptScore W4243774516C87753298 @default.
- W4243774516 hasConceptScore W4243774516C95444343 @default.
- W4243774516 hasConceptScore W4243774516C98274493 @default.
- W4243774516 hasLocation W42437745161 @default.
- W4243774516 hasLocation W42437745162 @default.
- W4243774516 hasOpenAccess W4243774516 @default.
- W4243774516 hasPrimaryLocation W42437745161 @default.
- W4243774516 hasRelatedWork W1967985044 @default.
- W4243774516 hasRelatedWork W2032202277 @default.
- W4243774516 hasRelatedWork W2045834561 @default.
- W4243774516 hasRelatedWork W2090867290 @default.
- W4243774516 hasRelatedWork W2122291074 @default.
- W4243774516 hasRelatedWork W2157421641 @default.
- W4243774516 hasRelatedWork W2389831585 @default.
- W4243774516 hasRelatedWork W2996109972 @default.
- W4243774516 hasRelatedWork W3109797254 @default.
- W4243774516 hasRelatedWork W4243774516 @default.
- W4243774516 isParatext "false" @default.
- W4243774516 isRetracted "false" @default.
- W4243774516 workType "article" @default.