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- W4243811127 abstract "The arrangement and movements of mitochondria were quantitatively studied in adult rat cardiomyocytes and in the cultured continuously dividing non beating NB HL-1 cells with differentiated cardiac phenotype. Mitochondria were stained using fluorescent dye MitoTrackerGreen, a dye associated with inner membrane of mitochondria, and studied by fluorescent confocal microscopy. Imaging during different time intervals made it possible to visualize the 2-dimensional movements and dynamics of cardiac mitochondria. In adult cardiac cells mitochondria were always arranged very regularly in a crystal-like manner and did not show any changes in their position during 30 min of low speed scanning. However, high speed scanning (pixel dwell time 3 ms, time interval between images 400 ms) revealed very rapid fluctuations of the positions of fluorescence centers which followed the pattern of a random walk movement within the limits of the internal space of mitochondria, most probably due to transitions between condensed and orthodox configurational states of matrix and inner membrane as a result of functioning of transmembrane metabolite carriers. No evidence for mitochondrial fusion or fission was found in adult cardiomyocytes. In contrast, in NB HL-1 cells, mitochondria were arranged as a dense tubular network, in permanent fusion, fission and displacement with high velocity around 90 nm/s. The differences observed are related to specific structural organization of the cells, and most probably due to differences in mitochondria-cytoskeleton organization. Intracellular local restrictions of diffusion of adenine nucleotides and metabolic feedback regulation of respiration via phosphotransfer networks are also different in these cells." @default.
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- W4243811127 date "2009-02-01" @default.
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- W4243811127 title "Mitochondrial Dynamics In Heart Cells: Very Low Amplitude High Frequency Fluctuations In Adult Cardiomyocytes And Flow Motion In Non-beating Hl-1 Cells" @default.
- W4243811127 doi "https://doi.org/10.1016/j.bpj.2008.12.1197" @default.
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