Matches in SemOpenAlex for { <https://semopenalex.org/work/W4243864562> ?p ?o ?g. }
Showing items 1 to 81 of
81
with 100 items per page.
- W4243864562 endingPage "268" @default.
- W4243864562 startingPage "260" @default.
- W4243864562 abstract "We have previously shown that the hepatic acute-phase protein alpha 1- antitrypsin (alpha 1-AT) inhibits transferrin (tf) binding to its receptor (tfR) of human placental membranes. To evaluate the possibility that this interaction can explain the pathophysiology of the changes in iron metabolism in the course of chronic disease, subsequently leading to anemia in chronic disease (ACD), we examined the effect of alpha 1-AT on cells of the erythroid cell line. alpha 1- AT completely prevented tf binding to tfR on K562 human erythroleukemic cells and on reticulocytes. This inhibitory potency was dose-dependent and competitive, as proved in equilibrium saturation and kinetic studies. The cytokines interleukin-1 (IL-1), IL-6, and tumor necrosis factor alpha showed no such effect. Internalization of the tf-tfR complex was inhibited with alpha 1-AT in a dose-dependent manner. Furthermore, alpha 1-AT profoundly reduced the growth of K562 cells as well as their proliferation, albeit to a lesser degree. Growth of early erythroid progenitor cells (burst-forming units-erythroid) was significantly suppressed by alpha 1-AT, but no effect on the growth of late erythroid progenitor cells (colony-forming units-erythroid) was detected. These inhibitions of alpha 1-AT were seen in high physiologic concentrations attained in the course of acute-phase situations. These data show that alpha 1-AT might be a mediator of the changes in iron metabolism that are characteristic of clinical findings in the course of ACD." @default.
- W4243864562 created "2022-05-12" @default.
- W4243864562 creator A5021321712 @default.
- W4243864562 creator A5050589523 @default.
- W4243864562 creator A5053268191 @default.
- W4243864562 creator A5077667455 @default.
- W4243864562 creator A5077943903 @default.
- W4243864562 date "1994-01-01" @default.
- W4243864562 modified "2023-10-17" @default.
- W4243864562 title "The acute-phase protein alpha 1-antitrypsin inhibits growth and proliferation of human early erythroid progenitor cells (burst-forming units-erythroid) and of human erythroleukemic cells (K562) in vitro by interfering with transferrin iron uptake" @default.
- W4243864562 doi "https://doi.org/10.1182/blood.v83.1.260.bloodjournal831260" @default.
- W4243864562 hasPublicationYear "1994" @default.
- W4243864562 type Work @default.
- W4243864562 citedByCount "0" @default.
- W4243864562 crossrefType "journal-article" @default.
- W4243864562 hasAuthorship W4243864562A5021321712 @default.
- W4243864562 hasAuthorship W4243864562A5050589523 @default.
- W4243864562 hasAuthorship W4243864562A5053268191 @default.
- W4243864562 hasAuthorship W4243864562A5077667455 @default.
- W4243864562 hasAuthorship W4243864562A5077943903 @default.
- W4243864562 hasBestOaLocation W42438645621 @default.
- W4243864562 hasConcept C134018914 @default.
- W4243864562 hasConcept C153911025 @default.
- W4243864562 hasConcept C159110408 @default.
- W4243864562 hasConcept C171122931 @default.
- W4243864562 hasConcept C201750760 @default.
- W4243864562 hasConcept C202751555 @default.
- W4243864562 hasConcept C203014093 @default.
- W4243864562 hasConcept C22814914 @default.
- W4243864562 hasConcept C2775944032 @default.
- W4243864562 hasConcept C28328180 @default.
- W4243864562 hasConcept C32264632 @default.
- W4243864562 hasConcept C49453240 @default.
- W4243864562 hasConcept C502942594 @default.
- W4243864562 hasConcept C54355233 @default.
- W4243864562 hasConcept C55493867 @default.
- W4243864562 hasConcept C64943373 @default.
- W4243864562 hasConcept C71924100 @default.
- W4243864562 hasConcept C81885089 @default.
- W4243864562 hasConcept C86803240 @default.
- W4243864562 hasConcept C95444343 @default.
- W4243864562 hasConceptScore W4243864562C134018914 @default.
- W4243864562 hasConceptScore W4243864562C153911025 @default.
- W4243864562 hasConceptScore W4243864562C159110408 @default.
- W4243864562 hasConceptScore W4243864562C171122931 @default.
- W4243864562 hasConceptScore W4243864562C201750760 @default.
- W4243864562 hasConceptScore W4243864562C202751555 @default.
- W4243864562 hasConceptScore W4243864562C203014093 @default.
- W4243864562 hasConceptScore W4243864562C22814914 @default.
- W4243864562 hasConceptScore W4243864562C2775944032 @default.
- W4243864562 hasConceptScore W4243864562C28328180 @default.
- W4243864562 hasConceptScore W4243864562C32264632 @default.
- W4243864562 hasConceptScore W4243864562C49453240 @default.
- W4243864562 hasConceptScore W4243864562C502942594 @default.
- W4243864562 hasConceptScore W4243864562C54355233 @default.
- W4243864562 hasConceptScore W4243864562C55493867 @default.
- W4243864562 hasConceptScore W4243864562C64943373 @default.
- W4243864562 hasConceptScore W4243864562C71924100 @default.
- W4243864562 hasConceptScore W4243864562C81885089 @default.
- W4243864562 hasConceptScore W4243864562C86803240 @default.
- W4243864562 hasConceptScore W4243864562C95444343 @default.
- W4243864562 hasIssue "1" @default.
- W4243864562 hasLocation W42438645621 @default.
- W4243864562 hasOpenAccess W4243864562 @default.
- W4243864562 hasPrimaryLocation W42438645621 @default.
- W4243864562 hasRelatedWork W1280128 @default.
- W4243864562 hasRelatedWork W2040820 @default.
- W4243864562 hasRelatedWork W22185118 @default.
- W4243864562 hasRelatedWork W31914251 @default.
- W4243864562 hasRelatedWork W38320945 @default.
- W4243864562 hasRelatedWork W4209463 @default.
- W4243864562 hasRelatedWork W436126 @default.
- W4243864562 hasRelatedWork W43675158 @default.
- W4243864562 hasRelatedWork W48588851 @default.
- W4243864562 hasRelatedWork W767785 @default.
- W4243864562 hasVolume "83" @default.
- W4243864562 isParatext "false" @default.
- W4243864562 isRetracted "false" @default.
- W4243864562 workType "article" @default.