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- W4243900364 abstract "Decreased brain perfusion, as shown by SPECT imaging, is associated with increased risk of cognitive decline and dementia. Noninvasive measurement of cerebral blood flow (CBF) using arterial spin labeling (ASL) MRI provides an opportunity to examine how CBF may lead to key neurodegenerative changes (e.g., brain volume loss, high WMH burden) associated with increased risk of dementia. In this context, we examined ASL CBF, as a potential functional marker of increased neurodegenerative risk in nondemented elderly. 49 non-demented volunteers (mean age 85, MMSE 28.5) underwent 3T MRI (Siemens Trio), including structural and Q2TIPS PASL sequences and detailed cognitive and neurological assessment. Automated WMH volumes were obtained from FLAIR images using a customized routine, segmented into deep and periventricular WMHs and log transformed when necessary to account for skewed distributions. Brain, hippocampal, and WM volumes were obtained using FreeSurfer 5.1. WMHs were subtracted from total WM to obtain normal appearing white matter (NAWM) masks, which were co-registered, along with cortical and subcortical gray matter maps to M0 ASL sequences to obtain regional CBF values (ml/100g/min). Differences in total WMH and NAWM CBF were examined using matched pairs t-tests. Linear regressions determined associations between CBF, brain volumes, and subject characteristics. Multivariate linear regression analyses examined relationships between regional CBF and brain volumes, adjusted for relevant variables. Decreased WM and NAWM CBF, but not cortical or subcortical GM CBF, were associated with increased age, and hypertension (HTN). CBF measures were not associated with MMSE. NAWM CBF was significantly higher than total WM CBF. After adjusting for age, gender, HTN, and intracranial volume, Greater PV, but not deep, WMH was associated with decreased WM and NAWM CBF; decreased total brain volume was associated with lower cortical CBF; and decreased hippocampal volume was associated with higher subcortical CBF. Regional ASL-derived CBF is associated with brain volume change in nondemented elderly at risk for dementia. The inclusion of ASL with structural MRI may enhance the ability to detect those at risk for cognitive decline, and provide a functional biomarker in prevention and treatment trials aimed at improving cerebral perfusion in the elderly." @default.
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- W4243900364 date "2013-07-01" @default.
- W4243900364 modified "2023-09-27" @default.
- W4243900364 title "P1-304: Arterial spin labeling cerebral blood flow and brain volumes in dementia-free elderly" @default.
- W4243900364 doi "https://doi.org/10.1016/j.jalz.2013.05.530" @default.
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