Matches in SemOpenAlex for { <https://semopenalex.org/work/W4243923162> ?p ?o ?g. }
- W4243923162 endingPage "58" @default.
- W4243923162 startingPage "41" @default.
- W4243923162 abstract "Understanding the dynamics of naive and memory CD4+ T cells in the immune response to HIV-1 infection can help elucidate typical disease progression patterns observed in HIV-1 patients. Although infection markers such as CD4+ T-cell count and viral load are monitored in patient blood, the lymphatic tissues (LT) have been shown to be an important viral reservoir. Here, we introduce the first comprehensive theoretical model of disease progression based on T-cell subsets and virus circulating between the two compartments of LT and blood. We use this model to predict several trademarks observed in adult HIV-1 disease progression such as the establishment of a setpoint in the asymptomatic stage. Our model predicts that both host and viral elements play a role in determining different disease progression patterns. Viral factors include viral infectivity and production rates, whereas host factors include elements of specific immunity. We also predict the effect of highly active antiretroviral therapy and treatment cessation on cellular and viral dynamics in both blood and LT." @default.
- W4243923162 created "2022-05-12" @default.
- W4243923162 creator A5038066460 @default.
- W4243923162 creator A5041966499 @default.
- W4243923162 creator A5050443184 @default.
- W4243923162 creator A5067786863 @default.
- W4243923162 date "2002-05-01" @default.
- W4243923162 modified "2023-10-13" @default.
- W4243923162 title "Dynamics of Naive and Memory CD4+ T Lymphocytes in HIV-1 Disease Progression" @default.
- W4243923162 cites W1487049617 @default.
- W4243923162 cites W1515775405 @default.
- W4243923162 cites W1527114757 @default.
- W4243923162 cites W1536536278 @default.
- W4243923162 cites W1580217007 @default.
- W4243923162 cites W1585570459 @default.
- W4243923162 cites W1619960357 @default.
- W4243923162 cites W1670606046 @default.
- W4243923162 cites W1733999086 @default.
- W4243923162 cites W1964712337 @default.
- W4243923162 cites W1964976518 @default.
- W4243923162 cites W1970856648 @default.
- W4243923162 cites W1973503572 @default.
- W4243923162 cites W1974393084 @default.
- W4243923162 cites W1976828027 @default.
- W4243923162 cites W1979000541 @default.
- W4243923162 cites W1980782206 @default.
- W4243923162 cites W1982448824 @default.
- W4243923162 cites W1984907301 @default.
- W4243923162 cites W1985376961 @default.
- W4243923162 cites W1989819664 @default.
- W4243923162 cites W1990398742 @default.
- W4243923162 cites W1990768351 @default.
- W4243923162 cites W1992991204 @default.
- W4243923162 cites W2001276044 @default.
- W4243923162 cites W2001933532 @default.
- W4243923162 cites W2011103103 @default.
- W4243923162 cites W2011646391 @default.
- W4243923162 cites W2012524901 @default.
- W4243923162 cites W2014984955 @default.
- W4243923162 cites W2021367723 @default.
- W4243923162 cites W2021497059 @default.
- W4243923162 cites W2022098233 @default.
- W4243923162 cites W2024473105 @default.
- W4243923162 cites W2028362346 @default.
- W4243923162 cites W2029738611 @default.
- W4243923162 cites W2030844138 @default.
- W4243923162 cites W2031037912 @default.
- W4243923162 cites W2031937335 @default.
- W4243923162 cites W2032299049 @default.
- W4243923162 cites W2037645700 @default.
- W4243923162 cites W2047125790 @default.
- W4243923162 cites W2049947898 @default.
- W4243923162 cites W2054964256 @default.
- W4243923162 cites W2055207797 @default.
- W4243923162 cites W2060829964 @default.
- W4243923162 cites W2061657962 @default.
- W4243923162 cites W2065608903 @default.
- W4243923162 cites W2065973980 @default.
- W4243923162 cites W2067230527 @default.
- W4243923162 cites W2070705992 @default.
- W4243923162 cites W2075330326 @default.
- W4243923162 cites W2075956283 @default.
- W4243923162 cites W2076400397 @default.
- W4243923162 cites W2079037246 @default.
- W4243923162 cites W2081567999 @default.
- W4243923162 cites W2082475264 @default.
- W4243923162 cites W2085396023 @default.
- W4243923162 cites W2089097515 @default.
- W4243923162 cites W2090384967 @default.
- W4243923162 cites W2090642065 @default.
- W4243923162 cites W2092509730 @default.
- W4243923162 cites W2094583956 @default.
- W4243923162 cites W2095180354 @default.
- W4243923162 cites W2096584806 @default.
- W4243923162 cites W2100850302 @default.
- W4243923162 cites W2102145741 @default.
- W4243923162 cites W2106051882 @default.
- W4243923162 cites W2107022943 @default.
- W4243923162 cites W2108256128 @default.
- W4243923162 cites W2114654929 @default.
- W4243923162 cites W2125787947 @default.
- W4243923162 cites W2130719514 @default.
- W4243923162 cites W2135816279 @default.
- W4243923162 cites W2138901765 @default.
- W4243923162 cites W2140712036 @default.
- W4243923162 cites W2142294933 @default.
- W4243923162 cites W2144010988 @default.
- W4243923162 cites W2158035002 @default.
- W4243923162 cites W2160131052 @default.
- W4243923162 cites W2162123874 @default.
- W4243923162 cites W2163345314 @default.
- W4243923162 cites W2163629954 @default.
- W4243923162 cites W2268215597 @default.
- W4243923162 cites W2319657764 @default.
- W4243923162 cites W2320498484 @default.
- W4243923162 cites W2332427171 @default.
- W4243923162 cites W2339006876 @default.
- W4243923162 cites W2406858656 @default.