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- W4243948611 abstract "Abstract A short enantioselective total synthesis of englerin A, a guaiane sesquiterpene with significant in vitro antitumor activity, is reported. Key features of this total synthesis are an organocatalytic asymmetric decarboxylative aldol reaction, a neighboring‐group‐participating [4+3] cycloaddition, a novel one‐pot Heck coupling/regioselective 1,4‐hydrosilylation/Tamao–Fleming oxidation cascade, and a kinetic CBS reduction, generating the optically pure natural product in 6.7 % overall yield over twelve steps starting from methylglyoxal. Selective saponification of the more reactive glycolic ester moiety of englerin A also gave (−)‐englerin B." @default.
- W4243948611 created "2022-05-12" @default.
- W4243948611 creator A5041574095 @default.
- W4243948611 creator A5082588682 @default.
- W4243948611 date "2019-05-10" @default.
- W4243948611 modified "2023-10-16" @default.
- W4243948611 title "β‐Ketoesters as Mono‐ or Bisnucleophiles: A Concise Enantioselective Total Synthesis of (−)‐Englerin A and B" @default.
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- W4243948611 doi "https://doi.org/10.1002/ange.201900401" @default.
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