Matches in SemOpenAlex for { <https://semopenalex.org/work/W4243963259> ?p ?o ?g. }
Showing items 1 to 97 of
97
with 100 items per page.
- W4243963259 endingPage "209" @default.
- W4243963259 startingPage "205" @default.
- W4243963259 abstract "Background and objective: Clonidine has cardiac and systemic effects that can modify the potentially lethal cardiovascular effects of local anaesthetics. We evaluated the effects of clonidine pre-treatment on cardiotoxicity induced by an infusion of bupivacaine or ropivacaine and the success rate of resuscitation in anaesthetized rats. Methods: Thirty-two Sprague-Dawley rats (250-300 g) were anaesthetized with thiopental and ketamine. Lung ventilation was maintained mechanically, and the electrocardiograph and invasive blood pressure were recorded continuously. Two separate groups of rats were treated with intravenous clonidine 5 μg kg−1 (n = 16) or saline (n = 16) in a randomized fashion. Fifteen minutes later, each group was randomly subdivided into two equal groups and an infusion of bupivacaine or ropivacaine, 3 mg kg−1 min−1, was given until cardiac arrest (asystole) occurred. The times when the cardiotoxic events (25%, 50% and 75% reduction of arterial pressure and heart rate, first dysrhythmia and asystole, respectively), induced by the local anaesthetic, occurred and the resuscitation outcome scores were recorded. Results: Clonidine reduced heart rate and arterial pressure (P < 0.01). Clonidine did not alter cardiotoxicity or the success rate of resuscitation in bupivacaine-treated rats. In the ropivacaine group, clonidine increased the 25%, 50% and 75% reduction times of arterial pressure and the 50% and 75% reduction times of heart rate, times to first dysrhythmia and asystole (P < 0.05). Clonidine also increased the success rate of resuscitation in ropivacaine-treated rats (P < 0.05). Conclusions: Although pre-treatment with clonidine protects the effects of ropivacaine cardiotoxicity and increases the success rate of resuscitation, it does not affect bupivacaine toxicity." @default.
- W4243963259 created "2022-05-12" @default.
- W4243963259 creator A5001516938 @default.
- W4243963259 creator A5012622587 @default.
- W4243963259 creator A5032715098 @default.
- W4243963259 creator A5041306222 @default.
- W4243963259 creator A5057432544 @default.
- W4243963259 date "2004-03-01" @default.
- W4243963259 modified "2023-09-29" @default.
- W4243963259 title "Effects of clonidine pre-treatment on bupivacaine and ropivacaine cardiotoxicity in rats" @default.
- W4243963259 cites W1964392630 @default.
- W4243963259 cites W1964699862 @default.
- W4243963259 cites W1965232609 @default.
- W4243963259 cites W1969530011 @default.
- W4243963259 cites W1989924100 @default.
- W4243963259 cites W1992656437 @default.
- W4243963259 cites W1992985735 @default.
- W4243963259 cites W2003341466 @default.
- W4243963259 cites W2016625087 @default.
- W4243963259 cites W2024377380 @default.
- W4243963259 cites W2028751490 @default.
- W4243963259 cites W2041514975 @default.
- W4243963259 cites W2067040304 @default.
- W4243963259 cites W2067847386 @default.
- W4243963259 cites W2088841084 @default.
- W4243963259 cites W2092576934 @default.
- W4243963259 cites W2092697768 @default.
- W4243963259 cites W2128715562 @default.
- W4243963259 cites W2150310797 @default.
- W4243963259 cites W2158515028 @default.
- W4243963259 cites W2327810205 @default.
- W4243963259 doi "https://doi.org/10.1097/00003643-200403000-00007" @default.
- W4243963259 hasPublicationYear "2004" @default.
- W4243963259 type Work @default.
- W4243963259 citedByCount "12" @default.
- W4243963259 countsByYear W42439632592012 @default.
- W4243963259 countsByYear W42439632592013 @default.
- W4243963259 countsByYear W42439632592015 @default.
- W4243963259 countsByYear W42439632592016 @default.
- W4243963259 countsByYear W42439632592020 @default.
- W4243963259 countsByYear W42439632592021 @default.
- W4243963259 crossrefType "journal-article" @default.
- W4243963259 hasAuthorship W4243963259A5001516938 @default.
- W4243963259 hasAuthorship W4243963259A5012622587 @default.
- W4243963259 hasAuthorship W4243963259A5032715098 @default.
- W4243963259 hasAuthorship W4243963259A5041306222 @default.
- W4243963259 hasAuthorship W4243963259A5057432544 @default.
- W4243963259 hasBestOaLocation W42439632591 @default.
- W4243963259 hasConcept C126322002 @default.
- W4243963259 hasConcept C141071460 @default.
- W4243963259 hasConcept C2776452961 @default.
- W4243963259 hasConcept C2776694085 @default.
- W4243963259 hasConcept C2776818218 @default.
- W4243963259 hasConcept C2777953023 @default.
- W4243963259 hasConcept C2778165595 @default.
- W4243963259 hasConcept C2778233292 @default.
- W4243963259 hasConcept C2778399450 @default.
- W4243963259 hasConcept C2780269707 @default.
- W4243963259 hasConcept C2781328992 @default.
- W4243963259 hasConcept C42219234 @default.
- W4243963259 hasConcept C71924100 @default.
- W4243963259 hasConcept C84393581 @default.
- W4243963259 hasConceptScore W4243963259C126322002 @default.
- W4243963259 hasConceptScore W4243963259C141071460 @default.
- W4243963259 hasConceptScore W4243963259C2776452961 @default.
- W4243963259 hasConceptScore W4243963259C2776694085 @default.
- W4243963259 hasConceptScore W4243963259C2776818218 @default.
- W4243963259 hasConceptScore W4243963259C2777953023 @default.
- W4243963259 hasConceptScore W4243963259C2778165595 @default.
- W4243963259 hasConceptScore W4243963259C2778233292 @default.
- W4243963259 hasConceptScore W4243963259C2778399450 @default.
- W4243963259 hasConceptScore W4243963259C2780269707 @default.
- W4243963259 hasConceptScore W4243963259C2781328992 @default.
- W4243963259 hasConceptScore W4243963259C42219234 @default.
- W4243963259 hasConceptScore W4243963259C71924100 @default.
- W4243963259 hasConceptScore W4243963259C84393581 @default.
- W4243963259 hasIssue "3" @default.
- W4243963259 hasLocation W42439632591 @default.
- W4243963259 hasLocation W42439632592 @default.
- W4243963259 hasOpenAccess W4243963259 @default.
- W4243963259 hasPrimaryLocation W42439632591 @default.
- W4243963259 hasRelatedWork W1973427318 @default.
- W4243963259 hasRelatedWork W1973629912 @default.
- W4243963259 hasRelatedWork W1992919052 @default.
- W4243963259 hasRelatedWork W2018596605 @default.
- W4243963259 hasRelatedWork W2035322323 @default.
- W4243963259 hasRelatedWork W2071201819 @default.
- W4243963259 hasRelatedWork W2407178312 @default.
- W4243963259 hasRelatedWork W2409804740 @default.
- W4243963259 hasRelatedWork W2510014264 @default.
- W4243963259 hasRelatedWork W4243963259 @default.
- W4243963259 hasVolume "21" @default.
- W4243963259 isParatext "false" @default.
- W4243963259 isRetracted "false" @default.
- W4243963259 workType "article" @default.