Matches in SemOpenAlex for { <https://semopenalex.org/work/W4243977010> ?p ?o ?g. }
Showing items 1 to 73 of
73
with 100 items per page.
- W4243977010 abstract "Abstract Exposure to bisphenol A (BPA) contributes to neurological disorders, but the underlying mechanisms are still not completely understood. We studied the neurotoxic effect of BPA and how it promotes inflammation and alteration in the neurotransmission synthesis, release and transmission. This study was also designed to investigate the neuroprotective effect of grape seed proanthocyanidins (GSPE) against BPA-induced neurotoxicity in rats. Rats were equally divided into 4 group with 7 rats in each as follows: control group, BPA group, GSPE + BPA group and GSPE group. Rats were orally treated with their respective doses (50 mg BPA/kg BW and/or 200 mg GSPE/kg BW) daily for 70 days. BPA elicits significant elevation in malondialdehyde (MDA) and nitric oxide (NO) associated with significant reduction in glutathione (GSH), total thiols, glutathione peroxidase (GPx), superoxide dismutase (SOD) and glutathione-S-transferase (GST). BPA exposure result in increased dopamine and serotonin levels, elevation in acetylcholine esterase (AchE) activity and reduction in Na/K-ATPase and total ATPase activities in the brain. Also, BPA induces upregulation in the gene expression of the inflammatory markers; tumor necrosis factor-α (TNF-α) and cyclooxygenase-2 (COX-2), and in the tumor suppressor and pro-oxidant p53 protein. The pretreatment with GSPE attenuate or ameliorate all the oxidative and neurotoxic parameters induced by BPA. Our results suggest that GSPE has a promising role in modulating BPA-induced neuroinflammation and neurotoxicity and its antioxidant and free radical scavenging activities may in part be responsible for such effects." @default.
- W4243977010 created "2022-05-12" @default.
- W4243977010 creator A5026850542 @default.
- W4243977010 creator A5028678534 @default.
- W4243977010 creator A5055501065 @default.
- W4243977010 creator A5065645630 @default.
- W4243977010 date "2021-06-08" @default.
- W4243977010 modified "2023-09-26" @default.
- W4243977010 title "Neurotoxicity and Neuroinflammatory Effects of Bisphenol A in Male Rats. The Neuroprotective Role of Grape Seeds Proanthocyanidins" @default.
- W4243977010 doi "https://doi.org/10.21203/rs.3.rs-544366/v1" @default.
- W4243977010 hasPublicationYear "2021" @default.
- W4243977010 type Work @default.
- W4243977010 citedByCount "0" @default.
- W4243977010 crossrefType "posted-content" @default.
- W4243977010 hasAuthorship W4243977010A5026850542 @default.
- W4243977010 hasAuthorship W4243977010A5028678534 @default.
- W4243977010 hasAuthorship W4243977010A5055501065 @default.
- W4243977010 hasAuthorship W4243977010A5065645630 @default.
- W4243977010 hasBestOaLocation W42439770101 @default.
- W4243977010 hasConcept C126322002 @default.
- W4243977010 hasConcept C178790620 @default.
- W4243977010 hasConcept C181199279 @default.
- W4243977010 hasConcept C185592680 @default.
- W4243977010 hasConcept C25498285 @default.
- W4243977010 hasConcept C2775838275 @default.
- W4243977010 hasConcept C2776151105 @default.
- W4243977010 hasConcept C2776914184 @default.
- W4243977010 hasConcept C2778401633 @default.
- W4243977010 hasConcept C2778760513 @default.
- W4243977010 hasConcept C2779491297 @default.
- W4243977010 hasConcept C29730261 @default.
- W4243977010 hasConcept C519581460 @default.
- W4243977010 hasConcept C538909803 @default.
- W4243977010 hasConcept C55493867 @default.
- W4243977010 hasConcept C71924100 @default.
- W4243977010 hasConcept C86803240 @default.
- W4243977010 hasConcept C87753298 @default.
- W4243977010 hasConcept C98274493 @default.
- W4243977010 hasConceptScore W4243977010C126322002 @default.
- W4243977010 hasConceptScore W4243977010C178790620 @default.
- W4243977010 hasConceptScore W4243977010C181199279 @default.
- W4243977010 hasConceptScore W4243977010C185592680 @default.
- W4243977010 hasConceptScore W4243977010C25498285 @default.
- W4243977010 hasConceptScore W4243977010C2775838275 @default.
- W4243977010 hasConceptScore W4243977010C2776151105 @default.
- W4243977010 hasConceptScore W4243977010C2776914184 @default.
- W4243977010 hasConceptScore W4243977010C2778401633 @default.
- W4243977010 hasConceptScore W4243977010C2778760513 @default.
- W4243977010 hasConceptScore W4243977010C2779491297 @default.
- W4243977010 hasConceptScore W4243977010C29730261 @default.
- W4243977010 hasConceptScore W4243977010C519581460 @default.
- W4243977010 hasConceptScore W4243977010C538909803 @default.
- W4243977010 hasConceptScore W4243977010C55493867 @default.
- W4243977010 hasConceptScore W4243977010C71924100 @default.
- W4243977010 hasConceptScore W4243977010C86803240 @default.
- W4243977010 hasConceptScore W4243977010C87753298 @default.
- W4243977010 hasConceptScore W4243977010C98274493 @default.
- W4243977010 hasLocation W42439770101 @default.
- W4243977010 hasOpenAccess W4243977010 @default.
- W4243977010 hasPrimaryLocation W42439770101 @default.
- W4243977010 hasRelatedWork W1819681544 @default.
- W4243977010 hasRelatedWork W1969555927 @default.
- W4243977010 hasRelatedWork W2066059435 @default.
- W4243977010 hasRelatedWork W2349006073 @default.
- W4243977010 hasRelatedWork W2784241584 @default.
- W4243977010 hasRelatedWork W2897905006 @default.
- W4243977010 hasRelatedWork W2999214677 @default.
- W4243977010 hasRelatedWork W3094521366 @default.
- W4243977010 hasRelatedWork W4294990704 @default.
- W4243977010 hasRelatedWork W4297019876 @default.
- W4243977010 isParatext "false" @default.
- W4243977010 isRetracted "false" @default.
- W4243977010 workType "article" @default.