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- W4243978929 abstract "Merkel cell carcinoma (MCC) is a rare skin cancer, probably of neuroendocrine origin, with approximately 470 new cases diagnosed in the United States annually. It affects mainly Caucasian individuals, in whom the tumor development is likely related to sun exposure and chronic immunosuppression. It is an aggressive tumor, and survival is dependent on tumor stage at presentation. Histologically, MCC is a “small blue cell” tumor, differentiated from small cell lung cancer (SCLC) and the small cell variant of melanoma by immunohistochemistry, using S-100, CK20, CK7, and TTF-1. While several genetic abnormalities have been reported, no strong pathogenetic correlation has been identified. The diagnostic evaluation includes CT imaging; octreotide and PET scans may be helpful in diagnosis and staging. Wide surgical excision with tumor-free margins is the primary mode of treatment for nonmetastatic disease, and sentinel lymph node biopsy is recommended for the staging of the disease. Adjuvant radiation therapy at 45–50 Gy to the primary site and involved lymph nodes can prevent local recurrences and may improve survival rates. Chemotherapy, patterned after regimens for SCLC, leads to tumor regression in up to 70% of cases with metastatic disease, but has no established role in the adjuvant setting." @default.
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- W4243978929 date "2006-05-12" @default.
- W4243978929 modified "2023-10-03" @default.
- W4243978929 title "Merkel Cell Carcinoma" @default.
- W4243978929 doi "https://doi.org/10.1002/0470030542.ch53" @default.
- W4243978929 hasPublicationYear "2006" @default.
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