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- W4243993897 abstract "The aging process is marked by a relatively subtle short-term decline in reproductive hormone outflow in men. However, the nominal 0.8–1.3% annual fall in systemic bioavailability of testosterone results in a reduction of 30–50% by the sixth through eighth decades of life. Low testosterone concentrations forecast relative sarcopenia, osteopenia, visceral fat accumulation, detectable cognitive impairment, and variable mood depression. Accordingly, the mechanisms driving progressive androgen deprivation are important to understand. To this end, age-associated alterations in three dominant sites of physiological control, namely the hypothalamus, pituitary gland, and testis, are highlighted. The cognate signals are gonadotropin-releasing hormone (GnRH), luteinizing hormone (LH), and testosterone, which jointly determine androgen availability via feedback and feedforward adaptations. According to this emergent notion, no single gland acts in isolation to maintain homeostasis. An integrative concept is underscored by highlighting how aging-related testosterone depletion is an ensemble outcome of deterioration of interlinked control." @default.
- W4243993897 created "2022-05-12" @default.
- W4243993897 creator A5003698342 @default.
- W4243993897 creator A5038480680 @default.
- W4243993897 creator A5059777426 @default.
- W4243993897 date "2004-01-01" @default.
- W4243993897 modified "2023-09-28" @default.
- W4243993897 title "An Ensemble Perspective of Aging-Related Hypoandrogenemia in Men" @default.
- W4243993897 cites W1018488365 @default.
- W4243993897 cites W131179554 @default.
- W4243993897 cites W136683754 @default.
- W4243993897 cites W1541886985 @default.
- W4243993897 cites W1884855324 @default.
- W4243993897 cites W1957574327 @default.
- W4243993897 cites W1965713219 @default.
- W4243993897 cites W1971029030 @default.
- W4243993897 cites W1973045635 @default.
- W4243993897 cites W1977367578 @default.
- W4243993897 cites W1980911368 @default.
- W4243993897 cites W1981843591 @default.
- W4243993897 cites W1984929581 @default.
- W4243993897 cites W1988480069 @default.
- W4243993897 cites W1988960647 @default.
- W4243993897 cites W1989458934 @default.
- W4243993897 cites W1992787418 @default.
- W4243993897 cites W1993584712 @default.
- W4243993897 cites W1993724156 @default.
- W4243993897 cites W1994435963 @default.
- W4243993897 cites W1999156215 @default.
- W4243993897 cites W2004288763 @default.
- W4243993897 cites W2008636504 @default.
- W4243993897 cites W2009914657 @default.
- W4243993897 cites W2011169412 @default.
- W4243993897 cites W2012573853 @default.
- W4243993897 cites W2012760043 @default.
- W4243993897 cites W2013770423 @default.
- W4243993897 cites W2019833955 @default.
- W4243993897 cites W2023348704 @default.
- W4243993897 cites W2032292657 @default.
- W4243993897 cites W2034380697 @default.
- W4243993897 cites W2035694608 @default.
- W4243993897 cites W2036978149 @default.
- W4243993897 cites W2038162032 @default.
- W4243993897 cites W2042761570 @default.
- W4243993897 cites W2043180744 @default.
- W4243993897 cites W2050502602 @default.
- W4243993897 cites W2052185075 @default.
- W4243993897 cites W2052652879 @default.
- W4243993897 cites W2058541337 @default.
- W4243993897 cites W2069142214 @default.
- W4243993897 cites W2072258435 @default.
- W4243993897 cites W2072850015 @default.
- W4243993897 cites W2074607818 @default.
- W4243993897 cites W2075116558 @default.
- W4243993897 cites W2077204677 @default.
- W4243993897 cites W2077889556 @default.
- W4243993897 cites W2078781039 @default.
- W4243993897 cites W2081975982 @default.
- W4243993897 cites W2082662520 @default.
- W4243993897 cites W2086647859 @default.
- W4243993897 cites W2090172200 @default.
- W4243993897 cites W2092790183 @default.
- W4243993897 cites W2094719820 @default.
- W4243993897 cites W2102240367 @default.
- W4243993897 cites W2104975911 @default.
- W4243993897 cites W2111938618 @default.
- W4243993897 cites W2113111777 @default.
- W4243993897 cites W2118434339 @default.
- W4243993897 cites W2127290405 @default.
- W4243993897 cites W2133753630 @default.
- W4243993897 cites W2148807607 @default.
- W4243993897 cites W2154849172 @default.
- W4243993897 cites W2157632660 @default.
- W4243993897 cites W2158337337 @default.
- W4243993897 cites W2159443425 @default.
- W4243993897 cites W2162602921 @default.
- W4243993897 cites W2163879447 @default.
- W4243993897 cites W2165530215 @default.
- W4243993897 cites W2168258937 @default.
- W4243993897 cites W2217388589 @default.
- W4243993897 cites W2221176331 @default.
- W4243993897 cites W2224747510 @default.
- W4243993897 cites W2326622737 @default.
- W4243993897 cites W2345043532 @default.
- W4243993897 cites W3022740901 @default.
- W4243993897 cites W39010816 @default.
- W4243993897 cites W4232369429 @default.
- W4243993897 cites W4232620432 @default.
- W4243993897 cites W4234298907 @default.
- W4243993897 cites W4234898564 @default.
- W4243993897 cites W4236201870 @default.
- W4243993897 cites W4237337285 @default.
- W4243993897 cites W4241407983 @default.
- W4243993897 cites W4243016183 @default.
- W4243993897 cites W4245404405 @default.
- W4243993897 cites W4246863604 @default.
- W4243993897 cites W4247027611 @default.
- W4243993897 cites W4247514592 @default.