Matches in SemOpenAlex for { <https://semopenalex.org/work/W4243996896> ?p ?o ?g. }
Showing items 1 to 90 of
90
with 100 items per page.
- W4243996896 endingPage "1657" @default.
- W4243996896 startingPage "1651" @default.
- W4243996896 abstract "The idiopathic hypereosinophilic syndrome (IHES) is a rare disorder characterized by unexplained, persistent eosinophilia associated with multiple organ dysfunction due to eosinophilic tissue infiltration. In the absence of karyotypic abnormalities, there is no specific test to detect clonal eosinophilia in IHES. Analysis of X-chromosome inactivation patterns can be used to determine whether proliferative disorders are clonal in origin. Methylation of HpaII andHha I sites near the polymorphic trinucleotide repeat of the human androgen receptor gene (HUMARA) has been shown to correlate with X-inactivation. In this study, we have used the polymerase chain reaction (PCR) with nested primers to analyze X-inactivation patterns of the HUMARA loci in purified eosinophils from female patients with eosinophilia. Peripheral blood eosinophils were isolated by their autofluoresence using flow cytometric sorting. Eosinophils purified from a female patient presenting with IHES were found to show a clonal pattern of X-inactivation. Eosinophil-depleted leukocytes from this patient were polyclonal by HUMARA analysis, thus excluding skewedness of random X-inactivation. After corticosteroid suppression of her blood eosinophilia, a clonal population of eosinophils could no longer be detected in purified eosinophils. In contrast, eosinophils purified from a patient with Churg-Strauss syndrome and from six patients with reactive eosinophilias attributed to allergy, parasitic infection, or drug reaction showed a polyclonal pattern of X-inactivation by HUMARA analysis. The finding of clonal eosinophilia in a patient presenting with IHES indicates that such patients may have, in reality, a low-grade clonal disorder that can be distinguished from reactive eosinophilias by HUMARA analysis. Further, the method described can be used to monitor disease progression." @default.
- W4243996896 created "2022-05-12" @default.
- W4243996896 creator A5025980131 @default.
- W4243996896 creator A5033957667 @default.
- W4243996896 creator A5066207678 @default.
- W4243996896 creator A5069580903 @default.
- W4243996896 date "1999-03-01" @default.
- W4243996896 modified "2023-10-10" @default.
- W4243996896 title "Clonality of Isolated Eosinophils in the Hypereosinophilic Syndrome" @default.
- W4243996896 cites W110944710 @default.
- W4243996896 cites W121104569 @default.
- W4243996896 cites W1663457857 @default.
- W4243996896 cites W1972031015 @default.
- W4243996896 cites W1983009417 @default.
- W4243996896 cites W2007671088 @default.
- W4243996896 cites W2038279587 @default.
- W4243996896 cites W2044327033 @default.
- W4243996896 cites W2051406511 @default.
- W4243996896 cites W2059455063 @default.
- W4243996896 cites W2091001503 @default.
- W4243996896 cites W2113885646 @default.
- W4243996896 cites W2124307602 @default.
- W4243996896 cites W2128973236 @default.
- W4243996896 cites W2150534327 @default.
- W4243996896 cites W2342251757 @default.
- W4243996896 cites W2408932444 @default.
- W4243996896 cites W2412199362 @default.
- W4243996896 cites W40765902 @default.
- W4243996896 cites W4231967402 @default.
- W4243996896 cites W4235940039 @default.
- W4243996896 cites W4293245940 @default.
- W4243996896 doi "https://doi.org/10.1182/blood.v93.5.1651.405k20_1651_1657" @default.
- W4243996896 hasPublicationYear "1999" @default.
- W4243996896 type Work @default.
- W4243996896 citedByCount "3" @default.
- W4243996896 crossrefType "journal-article" @default.
- W4243996896 hasAuthorship W4243996896A5025980131 @default.
- W4243996896 hasAuthorship W4243996896A5033957667 @default.
- W4243996896 hasAuthorship W4243996896A5066207678 @default.
- W4243996896 hasAuthorship W4243996896A5069580903 @default.
- W4243996896 hasConcept C104317684 @default.
- W4243996896 hasConcept C142724271 @default.
- W4243996896 hasConcept C159654299 @default.
- W4243996896 hasConcept C203014093 @default.
- W4243996896 hasConcept C2776042228 @default.
- W4243996896 hasConcept C2777037409 @default.
- W4243996896 hasConcept C2777129736 @default.
- W4243996896 hasConcept C2777621362 @default.
- W4243996896 hasConcept C2908647359 @default.
- W4243996896 hasConcept C49105822 @default.
- W4243996896 hasConcept C54355233 @default.
- W4243996896 hasConcept C71924100 @default.
- W4243996896 hasConcept C86803240 @default.
- W4243996896 hasConcept C956191 @default.
- W4243996896 hasConcept C99454951 @default.
- W4243996896 hasConceptScore W4243996896C104317684 @default.
- W4243996896 hasConceptScore W4243996896C142724271 @default.
- W4243996896 hasConceptScore W4243996896C159654299 @default.
- W4243996896 hasConceptScore W4243996896C203014093 @default.
- W4243996896 hasConceptScore W4243996896C2776042228 @default.
- W4243996896 hasConceptScore W4243996896C2777037409 @default.
- W4243996896 hasConceptScore W4243996896C2777129736 @default.
- W4243996896 hasConceptScore W4243996896C2777621362 @default.
- W4243996896 hasConceptScore W4243996896C2908647359 @default.
- W4243996896 hasConceptScore W4243996896C49105822 @default.
- W4243996896 hasConceptScore W4243996896C54355233 @default.
- W4243996896 hasConceptScore W4243996896C71924100 @default.
- W4243996896 hasConceptScore W4243996896C86803240 @default.
- W4243996896 hasConceptScore W4243996896C956191 @default.
- W4243996896 hasConceptScore W4243996896C99454951 @default.
- W4243996896 hasIssue "5" @default.
- W4243996896 hasLocation W42439968961 @default.
- W4243996896 hasOpenAccess W4243996896 @default.
- W4243996896 hasPrimaryLocation W42439968961 @default.
- W4243996896 hasRelatedWork W1974919129 @default.
- W4243996896 hasRelatedWork W1978548532 @default.
- W4243996896 hasRelatedWork W2007974220 @default.
- W4243996896 hasRelatedWork W2033104843 @default.
- W4243996896 hasRelatedWork W2151290236 @default.
- W4243996896 hasRelatedWork W2319022116 @default.
- W4243996896 hasRelatedWork W2398492611 @default.
- W4243996896 hasRelatedWork W3188045492 @default.
- W4243996896 hasRelatedWork W3211486609 @default.
- W4243996896 hasRelatedWork W2129245456 @default.
- W4243996896 hasVolume "93" @default.
- W4243996896 isParatext "false" @default.
- W4243996896 isRetracted "false" @default.
- W4243996896 workType "article" @default.