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- W4244027799 abstract "Inducible nitric oxide synthase (iNOS) is found in a variety of both inflammatory and structural cells. It is the enzyme responsible for the generation of nitric oxide (NO) from the oxidation of L -arginine to citrulline. The enzyme iNOS may be upregulated by cytokines and has an increased activity and expression in inflammatory states. The resultant generation of NO may be beneficial or deleterious in the pathogenesis of disease, depending in part on the amount of NO generated and the prevailing oxidant conditions in the tissue. The activity of iNOS can be assessed indirectly by the measurement of end products generated by this enzyme or directly by immunohistochemistry, northern or western blots. NO levels and iNOS expression correlate with disease activity and may play a vital part in both physiological and pathological states." @default.
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- W4244027799 date "2002-10-01" @default.
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- W4244027799 title "The role of inducible nitric oxide in health and disease" @default.
- W4244027799 doi "https://doi.org/10.1016/s0968-6053(02)90131-6" @default.
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