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- W4244079454 abstract "Abstract The Eps15 homology (EH) domain is a 100‐residue protein‐interaction module that consists of a pair of helix‐loop‐helix EF hand motifs. The second EF hand typically binds calcium tightly, providing structural stability. The EH domain is either found singly or in a series of two or three tandem repeats in a variety of eukaryotic proteins that are involved in endocytosis, vesicle transport, and signal transduction. Its function is to mediate interactions with Asn‐Pro‐Phe (NPF) sequences or related motifs that are also often repeated in ligand proteins. The structures, calcium coordination, and peptide binding modes of five monomeric EH domains have recently been elucidated, providing insights into their mechanisms of action." @default.
- W4244079454 created "2022-05-12" @default.
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- W4244079454 date "2004-03-05" @default.
- W4244079454 modified "2023-09-23" @default.
- W4244079454 title "EH Domain" @default.
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- W4244079454 doi "https://doi.org/10.1002/0470028637.met047" @default.
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