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- W4244100989 endingPage "144" @default.
- W4244100989 startingPage "128" @default.
- W4244100989 abstract "Therapies engineered to prolong clotting factor protein circulation time, manipulate the balance of pro-coagulant and anti-coagulant proteins, or introduce new genetic material to enable endogenous factor protein production dominate the clinical trial landscape of hemophilia. The availability of clotting factor concentrates and the establishment of primary prophylaxis have dramatically improved health outcomes for hemophilia patients. But, the burden of hemostatic therapy remains significant, and many barriers to consistent longitudinal use of prophylaxis exist. Several types of emerging therapeutics including engineered factor concentrates, substitutive therapies, rebalancing therapies, and gene transfer/editing all aim to reduce the challenges of current hemophilia treatment. Emerging treatment options may reduce treatment frequency or need for intravenous administration. They may also introduce new challenges in laboratory assessment of hemostasis. These novel therapies must not introduce significant new health risks and continue to support similar or improved outcomes. The potential ramifications of rebalancing the coagulation cascade, particularly in a stress or inflammatory state, or introduction of new genetic material are not trivial. The focus of this review is to provide an overview of active and recently completed clinical trials as well as emerging preclinical data investigating new therapeutic possibilities for hemophilia patients and potentially other rare bleeding disorders." @default.
- W4244100989 created "2022-05-12" @default.
- W4244100989 creator A5040056986 @default.
- W4244100989 creator A5063509147 @default.
- W4244100989 creator A5074654320 @default.
- W4244100989 date "2020-11-02" @default.
- W4244100989 modified "2023-10-14" @default.
- W4244100989 title "<scp>2021</scp>clinical trials update: Innovations in hemophilia therapy" @default.
- W4244100989 cites W1223459945 @default.
- W4244100989 cites W1498468945 @default.
- W4244100989 cites W1510414151 @default.
- W4244100989 cites W1552409234 @default.
- W4244100989 cites W1567796113 @default.
- W4244100989 cites W1658726562 @default.
- W4244100989 cites W1851966151 @default.
- W4244100989 cites W1969271703 @default.
- W4244100989 cites W1974965024 @default.
- W4244100989 cites W1976624075 @default.
- W4244100989 cites W1988197108 @default.
- W4244100989 cites W1994326519 @default.
- W4244100989 cites W1997085090 @default.
- W4244100989 cites W2006458114 @default.
- W4244100989 cites W2017568412 @default.
- W4244100989 cites W2027319450 @default.
- W4244100989 cites W2036867468 @default.
- W4244100989 cites W2044474105 @default.
- W4244100989 cites W2056869950 @default.
- W4244100989 cites W2059843712 @default.
- W4244100989 cites W2060437910 @default.
- W4244100989 cites W2082025265 @default.
- W4244100989 cites W2101407724 @default.
- W4244100989 cites W2104531050 @default.
- W4244100989 cites W2106662817 @default.
- W4244100989 cites W2111454506 @default.
- W4244100989 cites W2122304523 @default.
- W4244100989 cites W2139846563 @default.
- W4244100989 cites W2150447973 @default.
- W4244100989 cites W2166171010 @default.
- W4244100989 cites W2167801052 @default.
- W4244100989 cites W2170205772 @default.
- W4244100989 cites W2174393453 @default.
- W4244100989 cites W2193386956 @default.
- W4244100989 cites W2294122644 @default.
- W4244100989 cites W2295666590 @default.
- W4244100989 cites W2315516779 @default.
- W4244100989 cites W2333324224 @default.
- W4244100989 cites W2484083978 @default.
- W4244100989 cites W2509144358 @default.
- W4244100989 cites W2540515989 @default.
- W4244100989 cites W2561075414 @default.
- W4244100989 cites W2565753485 @default.
- W4244100989 cites W2591915455 @default.
- W4244100989 cites W2611209610 @default.
- W4244100989 cites W2656022649 @default.
- W4244100989 cites W2671028678 @default.
- W4244100989 cites W2729612066 @default.
- W4244100989 cites W2734287351 @default.
- W4244100989 cites W2734498030 @default.
- W4244100989 cites W2744114002 @default.
- W4244100989 cites W2754682981 @default.
- W4244100989 cites W2773253161 @default.
- W4244100989 cites W2784295509 @default.
- W4244100989 cites W2789385179 @default.
- W4244100989 cites W2801755334 @default.
- W4244100989 cites W2803207694 @default.
- W4244100989 cites W2804969681 @default.
- W4244100989 cites W2805065547 @default.
- W4244100989 cites W2806608489 @default.
- W4244100989 cites W2806905912 @default.
- W4244100989 cites W2808215790 @default.
- W4244100989 cites W2808414377 @default.
- W4244100989 cites W2888089667 @default.
- W4244100989 cites W2888314705 @default.
- W4244100989 cites W2888898681 @default.
- W4244100989 cites W2889304415 @default.
- W4244100989 cites W2889420604 @default.
- W4244100989 cites W2899078923 @default.
- W4244100989 cites W2900309452 @default.
- W4244100989 cites W2904482058 @default.
- W4244100989 cites W2907288153 @default.
- W4244100989 cites W2918847366 @default.
- W4244100989 cites W2922760315 @default.
- W4244100989 cites W2935773495 @default.
- W4244100989 cites W2936431988 @default.
- W4244100989 cites W2942665937 @default.
- W4244100989 cites W2943673261 @default.
- W4244100989 cites W2967232987 @default.
- W4244100989 cites W2969898037 @default.
- W4244100989 cites W2980324290 @default.
- W4244100989 cites W2980900975 @default.
- W4244100989 cites W2983057487 @default.
- W4244100989 cites W2986098563 @default.
- W4244100989 cites W2986841994 @default.
- W4244100989 cites W2988108855 @default.
- W4244100989 cites W2988281062 @default.
- W4244100989 cites W2989359658 @default.
- W4244100989 cites W2989911221 @default.
- W4244100989 cites W2990594927 @default.