Matches in SemOpenAlex for { <https://semopenalex.org/work/W4244122007> ?p ?o ?g. }
Showing items 1 to 85 of
85
with 100 items per page.
- W4244122007 endingPage "198" @default.
- W4244122007 startingPage "191" @default.
- W4244122007 abstract "Diffuse large cell lymphomas are aggressive tumors of B-cell origin. In some cases they arise from low-grade follicular lymphomas carrying the t(14;18) translocation, an event that leads to the overexpression of the BCL-2 gene product. More frequently, however, they lack the t(14;18) translocation. Rearrangements of the c-MYC proto-oncogene and mutations of the p53 tumor suppressor gene have also been documented in these lymphomas. This study examines the extent to which alterations in the BCL-2, c-MYC, and p53 genes co-exist within individual lymphomas. Eight diffuse large cell lymphoma cell lines and 11 diffuse large cell lymphoma tumors were assessed for genetic alterations in these three genes. Our results indicate that there is a heterogeneity in the oncogene/suppressor gene profile among diffuse large cell lymphomas. Two cell lines and one tumor carried alterations in all three genes, one cell line carried alterations of c-MYC and p53, and one primary tumor and one cell line carried p53 mutations and the t(14;18). Single alterations of BCL-2 and p53 were also observed. Another cell line had no alterations in any of these genes. The heterogeneity indicates that varied mechanisms may be involved in the generation of diffuse large cell lymphomas." @default.
- W4244122007 created "2022-05-12" @default.
- W4244122007 creator A5014477704 @default.
- W4244122007 creator A5028361826 @default.
- W4244122007 creator A5033133917 @default.
- W4244122007 creator A5052934335 @default.
- W4244122007 creator A5084792996 @default.
- W4244122007 date "1994-01-01" @default.
- W4244122007 modified "2023-10-15" @default.
- W4244122007 title "Alterations of the p53 tumor suppressor gene in diffuse large cell lymphomas with translocations of the c-MYC and BCL-2 proto-oncogenes" @default.
- W4244122007 doi "https://doi.org/10.1182/blood.v83.1.191.bloodjournal831191" @default.
- W4244122007 hasPublicationYear "1994" @default.
- W4244122007 type Work @default.
- W4244122007 citedByCount "2" @default.
- W4244122007 crossrefType "journal-article" @default.
- W4244122007 hasAuthorship W4244122007A5014477704 @default.
- W4244122007 hasAuthorship W4244122007A5028361826 @default.
- W4244122007 hasAuthorship W4244122007A5033133917 @default.
- W4244122007 hasAuthorship W4244122007A5052934335 @default.
- W4244122007 hasAuthorship W4244122007A5084792996 @default.
- W4244122007 hasBestOaLocation W42441220071 @default.
- W4244122007 hasConcept C104317684 @default.
- W4244122007 hasConcept C121608353 @default.
- W4244122007 hasConcept C138626823 @default.
- W4244122007 hasConcept C1491633281 @default.
- W4244122007 hasConcept C150194340 @default.
- W4244122007 hasConcept C179185449 @default.
- W4244122007 hasConcept C195286587 @default.
- W4244122007 hasConcept C203014093 @default.
- W4244122007 hasConcept C2777058707 @default.
- W4244122007 hasConcept C2778264664 @default.
- W4244122007 hasConcept C2778559949 @default.
- W4244122007 hasConcept C2778911148 @default.
- W4244122007 hasConcept C2779338263 @default.
- W4244122007 hasConcept C2779916150 @default.
- W4244122007 hasConcept C2781018059 @default.
- W4244122007 hasConcept C2781182431 @default.
- W4244122007 hasConcept C29537977 @default.
- W4244122007 hasConcept C502942594 @default.
- W4244122007 hasConcept C54355233 @default.
- W4244122007 hasConcept C555283112 @default.
- W4244122007 hasConcept C81885089 @default.
- W4244122007 hasConcept C86803240 @default.
- W4244122007 hasConceptScore W4244122007C104317684 @default.
- W4244122007 hasConceptScore W4244122007C121608353 @default.
- W4244122007 hasConceptScore W4244122007C138626823 @default.
- W4244122007 hasConceptScore W4244122007C1491633281 @default.
- W4244122007 hasConceptScore W4244122007C150194340 @default.
- W4244122007 hasConceptScore W4244122007C179185449 @default.
- W4244122007 hasConceptScore W4244122007C195286587 @default.
- W4244122007 hasConceptScore W4244122007C203014093 @default.
- W4244122007 hasConceptScore W4244122007C2777058707 @default.
- W4244122007 hasConceptScore W4244122007C2778264664 @default.
- W4244122007 hasConceptScore W4244122007C2778559949 @default.
- W4244122007 hasConceptScore W4244122007C2778911148 @default.
- W4244122007 hasConceptScore W4244122007C2779338263 @default.
- W4244122007 hasConceptScore W4244122007C2779916150 @default.
- W4244122007 hasConceptScore W4244122007C2781018059 @default.
- W4244122007 hasConceptScore W4244122007C2781182431 @default.
- W4244122007 hasConceptScore W4244122007C29537977 @default.
- W4244122007 hasConceptScore W4244122007C502942594 @default.
- W4244122007 hasConceptScore W4244122007C54355233 @default.
- W4244122007 hasConceptScore W4244122007C555283112 @default.
- W4244122007 hasConceptScore W4244122007C81885089 @default.
- W4244122007 hasConceptScore W4244122007C86803240 @default.
- W4244122007 hasIssue "1" @default.
- W4244122007 hasLocation W42441220071 @default.
- W4244122007 hasOpenAccess W4244122007 @default.
- W4244122007 hasPrimaryLocation W42441220071 @default.
- W4244122007 hasRelatedWork W13599526 @default.
- W4244122007 hasRelatedWork W16961552 @default.
- W4244122007 hasRelatedWork W19262469 @default.
- W4244122007 hasRelatedWork W25550095 @default.
- W4244122007 hasRelatedWork W27951056 @default.
- W4244122007 hasRelatedWork W34095788 @default.
- W4244122007 hasRelatedWork W3940352 @default.
- W4244122007 hasRelatedWork W41965769 @default.
- W4244122007 hasRelatedWork W46062892 @default.
- W4244122007 hasRelatedWork W49330675 @default.
- W4244122007 hasVolume "83" @default.
- W4244122007 isParatext "false" @default.
- W4244122007 isRetracted "false" @default.
- W4244122007 workType "article" @default.