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- W4244123466 abstract "Modest dysregulation of CK2 has been shown to enhance the oncogenic potential in transgenic models of cancer. Since nuclear matrix serves as an anchor for CK2 and plays a key role in growth-related activities, we examined the effects of CK2 overexpression on its signaling to the nuclear matrix. Expression plasmids pCI-CK2α, pCI-CK2β, and the bicistronic pCI-CK2αβ containing full length cDNAs encoding the various subunits were employed to transiently transfect two cell lines, BPH-1 and COS-1. Cytosol from transfected BPH-1 cells containing α or β or α + β or αβ showed a modest increase in CK2 activity by 26%, 1%, 20%, and 17%, respectively, over that in the controls transfected with pCI vector. However, the corresponding increase in CK2 activity in the NM fraction was 156%, 8%, 147%, and 152%, respectively. Immunoblot analysis of the CK2 in the NM accorded with these data. Similar results were obtained with COS-1 cells or other expression vectors. The results suggest that moderate overexpression of CK2 in the cells evokes a differential several-fold enhancement in NM associated CK2 relative to that in the cytosol. This process may have a bearing on the functional signaling of this kinase in relation to its possible role in oncogenesis. J. Cell. Biochem. 74:127–134, 1999. © 1999 Wiley-Liss, Inc." @default.
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- W4244123466 date "1999-07-01" @default.
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- W4244123466 title "Differential targeting of protein kinase CK2 to the nuclear matrix upon transient overexpression of its subunits" @default.
- W4244123466 doi "https://doi.org/10.1002/(sici)1097-4644(19990701)74:1<127::aid-jcb14>3.3.co;2-v" @default.
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